亚健康状态机体免疫功能改变与逍遥丸干预的效果  

Changes of Immune Function in Sub-healthy State and Effects of Xiaoyao Pill Intervention

作　　者：薛银萍[1] 李莲[1] 程琦 

机构地区：[1]石家庄市第一医院中西医结合科,石家庄050011

出　　处：《世界中医药》2017年第12期2939-2941,2945,共4页World Chinese Medicine

基　　金：2011年石家庄市科学技术研究与发展指导计划课题(第一批)(11146933)

摘　　要：目的:探讨亚健康人群的机体免疫功能状态,并分析方剂逍遥丸对其免疫功能的影响。方法:随机选取2015年5月至2016年2月就诊并确诊为肝郁脾虚型亚健康患者78例,均将其纳入观察组,予以口服中成药逍遥丸治疗,并在治疗前后对患者进行疲劳评定量表(FAI)及焦虑自评量表(SAS)测定,同时检测其血清中免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、Th17在治疗前后的变化,并将其与体检的健康成年人志愿者进行对照。结果:亚健康状态按症状分为郁闷不舒、胸胁胀痛、头晕目眩、食欲减退、月经不调等5种类型,其中月经不调型占比最大;观察组亚健康患者的SAS、FAI评分、Th17均较治疗前有明显降低(P<0.05);IgG和IgA水平明显上升(P<0.05)。结论:逍遥丸大大改善了亚健康人群的免疫能力,并且通过降低外周血Th17水平,逍遥丸可抑制Th17细胞的异常活化,抑制了机体T淋巴细胞功能亢进,修复了受损的免疫系统。Objective： To explore the immune function of sub-healthy people,and analyze the therapeutic effects of Xiaoyao Pill on immune function. Methods： A total of 78 cases of sub-healthy patients with liver depression and spleen deficiency pattern who were treated and diagnosed in our hospital from May 2015 to February 2016 were randomly included into the treatment group,and treated with oral administration of Chinese patent medicine Xiaoyao Pill. The fatigue assessment instrument（ FAI） and self-rating anxiety scale（ SAS） of patients before and after treatment were measured. And the changes of serum levels of immunoglobulin G（ IgG）,immunoglobulin A（ IgA）,T Helper 17（ Th17） Cells before and after treatment were detected. They were compared with healthy adult volunteers came to our hospital for physical examination. Results： According to the symptoms,sub-health state was divided into 5 types of depression and gloomy,distention pain in chest,dizzy,anorexia and abnormal menstruation. Among them,abnormal menstruation type accounted for the largest. In the treatment group,the SAS,FAI scores and Th17 were significantly decreased（ P〈0. 05）. Serum levels of IgG and IgA were significantly increased（ P〈0. 05）. Conclusion： Xiaoyao Pill can greatly improve the immunity of sub-health population,and can inhibit abnormal activation of Th17 cell by reducing the level of Th17 in peripheral blood,inhibit hyperfunction of T lymphocyte,as well as repair damaged immune system.

关 键 词：逍遥丸 亚健康 免疫功能 

分 类 号：R289.3[医药卫生—方剂学] R392[医药卫生—中药学]