急性加重慢性阻塞性肺疾病血清降钙素原与C-反应蛋白的测定及临床意义  

Detection and clinical significance of serum C-reactive protein and procalcitonin in acute exacerbation of chronic obstructive pulmonary disease patients

作　　者：赵瑛 陈胜海 陈文虎[3] 金秀萍 刘小香[3] 

机构地区：[1]绍兴市柯桥区中医医院检验科,浙江绍兴312030 [2]绍兴市柯桥区中医医院呼吸科,浙江绍兴312030 [3]杭州医学院基础医学部,浙江杭州310053

出　　处：《中国卫生检验杂志》2017年第24期3555-3557,共3页Chinese Journal of Health Laboratory Technology

基　　金：浙江省卫生高层次创新人才培养工程项目(浙卫发[2016]63号);2015年度高校国内访问学者专业发展项目(124)

摘　　要：目的探讨急性加重慢性阻塞性肺疾病(AECOPD)血清降钙素原(PCT)和C-反应蛋白(CRP)测定的临床价值。方法本院住院110例AECOPD患者,包括67例感染性AECOPD患者(感染组)和43例非感染性AECOPD患者(非感染组),另收集70例健康体检者为对照组,回顾性分析110例AECOPD治疗前、后及对照组血清PCT和CRP及WBC检测结果,并进行统计学分析。结果 AECOPD患者CRP、PCT和WBC治疗前均明显高于治疗后和对照组;治疗前感染组3项检测指标均明显高于非感染组,上述差异均有统计学意义(P<0.05);感染组治疗前后CRP、PCT和WBC水平差异有统计学意义(P<0.05);CRP和PCT诊断感染性AECOPD的灵敏度分别为89.6%和92.5%,明显高于WBC的55.2%,差异有统计学意义(P<0.05)。结论血清CRP和PCT可作为COPD急性加重的评估指标,对判断是否存在感染有一定的预测价值。Objective To explore the clinical significance of serum C-reactive protein（ CRP） and procalcitonin（ PCT） in acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods A total of 110 AECOPD patients were respectively reviewed and assigned into infection group（ 67 cases） and non-infection group（ 43 cases）,and 70 cases of healthy people were selected as control group. The test results of serum PCT,CRP and WBC of 110 cases of AECOPD before and after treatment in the control group were conducted for retrospective analysis. Results The levels of CRP,PCT and WBC in patients with AECOPD before and after treatment were significantly higher than those; the three indexes of AECOPD patients before treatment were significantly higher than those of non-infected patients,with the differences statistically significant（ P〈0. 05）. There was statistical significance on the differences of CRP,PCT and WBC levels in the infection group before and after treatment（ P〈0. 05）.The sensitivity of CRP and PCT in diagnosing infectious AECOPD was 89. 6% and 92. 5% respectively,which was significantly higher than that of WBC（ 55. 2%）,with the differences statistically significant（ P〈0. 05）. Conclusion Serum CRP and PCT can be used as evaluation indicators for AECOPD＇s severity increase,and have value to predict the infection of AECOPD.

关 键 词：慢性阻塞性肺疾病 降钙素原 C-反应蛋白 白细胞 诊断 

分 类 号：R563.9[医药卫生—呼吸系统]