附子药理作用的分子机制研究进展  

Research Progress of Molecular Mechanism of Pharmacological Effects of Fuzi

作　　者：邓晓红 黄建华 董竞成[1,2] 

机构地区：[1]复旦大学附属华山医院中西医结合科,上海200040 [2]复旦大学中西医结合研究院,上海200040

出　　处：《江西中医药大学学报》2018年第1期121-124,共4页Journal of Jiangxi University of Chinese Medicine

摘　　要：附子被称为"回阳救逆第一品",其主要有效成分是乌头类生物碱、多糖、皂苷等,具有强心、保护心肌细胞、抗心律失常、抗炎和镇痛、抗肿瘤等药理作用。为了解附子药理作用的分子机制,本文检索了Pub Med数据库中收录的有关附子及其成分的研究文献,发现附子及其成分可通过影响β肾上腺素能受体和NF-κB,AMPK,PI3K/Akt,BDNF等信号转导通路发挥药理作用。本文总结了附子及其成分药理作用的分子机制,为以后的研究提供一定的基础。Fuzi is known as＂the first one of restoring Yang for resuscitation＂with cardiotonic effect and the effects of protecting myocardial cells,anti-arrhythmia,anti-inflammation,analgesia and anti-tumor. Its main active compounds are aconite alkaloids,polysaccharides,saponin,etc. In order to understand the molecular mechanism,we searched Pub Med for literatures about Fuzi and its compounds and found that Fuzi exerts pharmacological effects through β-adrenergic receptors,NF-κB,AMPK,PI3 K/Akt,BDNF,etc. We summarized the molecular mechanism of Fuzi and its compounds with an aim of providing basic informations for future study.

关 键 词：附子 Β肾上腺素能受体 NF-ΚB AMPK 综述 

分 类 号：R285.5[医药卫生—中药学]