穴位中药离子导入合并中药巴布膏敷贴疗法治疗膝骨性关节炎长期随访评价  

Long-term Follow-up Evaluation of Applying Chinese Herbs by Iontophoresis on Acupoints Combined with Chinese Herbs Babu Plaster Application Therapy in the Treatment of Knee Osteoarthritis

作　　者：严攀[1] 周建伟 吴楠 赵菁菁[4] 皮燕[2] 张林[4] 王敏[4] 

机构地区：[1]四川省骨科医院,四川成都610041 [2]四川省中西医结合医院,四川成都610041 [3]河南中医药大学康复医学院,河南郑州450046 [4]四川省第二中医院,四川成都610031

出　　处：《四川中医》2018年第1期187-191,共5页Journal of Sichuan of Traditional Chinese Medicine

基　　金：四川省中医药管理局科研课题(编号:2014-B-039)

摘　　要：目的:观察穴位离子导入联合中药敷贴治疗膝骨性关节炎关节疼痛的长期临床疗效,为制定膝骨性关节炎的中医外治方案提供可靠的临床试验依据。方法:采用多中心、随机、对照研究方法,将符合纳入排除标准的117例膝骨性关节炎患者随机分为试验组和对照组。试验组采用穴位中药离子导入联合中药巴布膏敷贴,对照组采用扶他林乳胶剂导入联合酮洛芬贴片敷贴,两组受试者每天接受1次治疗,连续治疗14次。以疼痛强度、疼痛频度、疼痛持续时间等疼痛相关指标为主要指标,以关节功能、生活质量等疾病相关指标为次要指标,分别进行治疗结束时及结束后12周、结束后24周随访评价。结果:治疗结束时各指标改善治疗组优于对照组,组间对比均有显著差异(P<0.01),随访期各指标试验组均较治疗前极显著改善(P<0.01),WOMAC疼痛强度总分在12周、24周随访时试验组优于对照组(P<0.05)。疼痛频度、WOMAC关节功能总分、AIMS2-SF总分在12周随访时试验组优于对照组(P<0.05)。结论:穴位离子导入联合中药敷贴操作方便、安全,相对于西药组能有效改善膝骨性关节炎患者疼痛症状、功能活动障碍及生活质量,且具有较好的远期效应。Objective： To evaluate the long-term effectiveness of Chinese herbs by iontophoresis and application on acu- points for knee osteoarthritis pain and provide reliable clinical trial basis for operation scheme of traditional Chinese medicine external treatment of knee osteoarthritis. Methods： A multi-center, randomized and controlled trial was designed, l lTknee osteoarthritis patients who matched the inclusion and exclusion criteria were randomly divided into 2groups. Participants in the treatment group received Chinese herbs by iontophoresis and application on aeupoints. Participants in the controlled group received dichofenac diethylammon by iontophoresis and ketoprofen patch. Participants received treatment once per day and totally for 14days. The primary outcome was the pain intensity, pain frequency, the duration of the pain. The secondary outcome was the joint function and quality of life. To evaluate the comparison before and after treatment in the group and comparison between groups of each outcome at 12th and 24th week after treatment. Results ： All the pain-related outcomes of the treatment group was significantly improved after the treatment （P〈0.01）. All the follow-up outcomes were significantly better than baseline （P〈 0. 01 ）. AIMS2-SF score of the treatment group was significantly better than the controlled group at 12th and 24th week after treatment （P〈0.05） while the pain frequency, WOMAC score of pain intensity and physical function at 12th week only （P〈 0. 05 ）. Conclusion ： The Chinese herbs by iontophoresis and application on acupoints can effectively improve the symptoms of pain, joint function and quality of life for patients with knee osteoarthritis with satisfying long-term effects. It is better than herapeutic schedule of western medicine. The therapy with strong clinical applicability is safe, effective and easy to operate.

关 键 词：膝骨性关节炎 中医外治法 穴位离子导入 中药敷贴 

分 类 号：R245.9[医药卫生—针灸推拿学]