“双心医学”对冠心病伴抑郁和焦虑患者心率变异性及心功能的影响  

Psycho-cardiology therapy to coronary artery disease-patients with depression and anxiety can improve heart rate variability and cardiac function

作　　者：李松彪[1] 谭萃妍 

机构地区：[1]中山大学附属第五医院心内科,广东省珠海市519000

出　　处：《中国心血管病研究》2017年第12期1087-1090,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨“双心医学”对冠心病伴抑郁和焦虑患者心率变异性及心功能的影响。方法选择2014年1月1日至2016年12月30日在我院就诊的冠心病伴抑郁和焦虑患者150例，单盲随机分为观察组和对照组。对照组70例采用标准化冠心病治疗＋健康宣教方式；观察组80例在对照组治疗的基础上联合帕罗西汀治疗，比较两组治疗效果。结果两组在治疗前心率变异性指标、心室射血分数、心排血量、每心搏出量、抑郁自评量表和焦虑自评量表评分比较未见统计学差异（P〉0．05）；治疗后全部窦性心搏RR间期的。标准差、每5min的RR间期平均值的标准差、相邻RR间期差值均方的平方根、每5min内的RR间期标准差的平均值均升高，相邻RR间期差〉50ms的个数占总心跳次数的百分比的差异降低，左心射血分数及心排血量提高，每心搏出量增加，SDS及SAS评分降低。上述指标两组差异均具有统计学意义（P〈O．01）。结论双心治疗能够改善冠心病伴抑郁和焦虑患者心理状态及心功能，对促进患者治疗后重新融入社会有一定积极意义，值得临床推广。Objective To investigate the effects of Psycho-cardiology on heart rate variability and cardiac function in patients with anxiety and depression. Methods 150 cases of coronary heart disease with depression and anxiety from 1st January 2014 to 30th December 2016 administered in our hospital were collected and ana- lyzed. The patients were divided into experimental and control groups randomly. The 70 patients in control group were treated by standard treatment of coronary heart disease and health education. While 80 patients in the experi- mental group were accepted with Seroxat added to the standard treatment. Therapeutic effects were compared. Re- sults Heart rate variability index, left ventricular ejection fractions, cardiac outputs and stroke volume were all improved. SDS and SAS were decreased after treatment between these two groups, the differences were statistical significant （P〈0.01） after treatment between these two groups. Conclusion Psycho-cardiology can improve de- pression and anxiety in patients with coronary artery disease and heart function, promote patients to reintegrate into society.

关 键 词：冠状动脉疾病 抑郁 焦虑 

分 类 号：R541.4[医药卫生—心血管疾病]