注意缺陷多动障碍患儿认知发展的静息态功能磁共振研究  

Cognitive development of children with attention deficit hyperactivity disorder： a resting-state functional magnetic resonance imaging study

作　　者：江凯华[1] 郑爱斌 丁丽[1] 沈惠娟[1] 李红新[1] 刘建荣 

机构地区：[1]南通大学附属常州市儿童医院儿童健康研究中心,213003

出　　处：《中华实用儿科临床杂志》2018年第2期141-144,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：江苏省科技专项（BL2014037）;常州市卫生计生委重大科技项目（ZD201614）

摘　　要：目的采用静息态功能磁共振（fMRI）度中心度（DC）的方法，从神经影像的角度探索注意缺陷多动障碍（ADHD）患儿认知发展的特征。方法选取2015年6月至2016年12月在南通大学附属常州市儿童医院专科门诊确诊的ADHD患儿45例，根据年龄分为3组：7～8岁组、9～10岁组、11～12岁组，每组15例。对患儿进行静息态fMRI检查，采用DC值作为测量指标，3组不同年龄的ADHD患儿分别两两进行比较分析。结果9～10岁组较7～8岁组DC值降低的脑区为小脑后叶（t＝－4.36），DC值增高的脑区为顶下小叶（t＝5.86），差异均有统计学意义（均P〈0.05，校正后）；11～12岁组较7～8岁组DC值降低的脑区为小脑后叶（t＝－4.99），DC值增高的脑区为左侧颞下回（t＝5.18）和额上回（t＝4.58），差异均有统计学意义（均P〈0.05，校正后）；11～12岁组较9～10岁组DC值降低的脑区为顶下小叶（t＝－5.71），DC值增高的脑区为左侧颞下回（t＝5.05）和额上回（t＝4.36），差异均有统计学意义（均P〈0.05，校正后）。结论静息态下不同年龄ADHD患儿fMRI的脑区特征不同，这可为不同年龄ADHD患儿进行早期认知干预提供客观依据。ObjectiveTo investigate the characteristics of cognitive development of children with attention deficit hyperactivity disorder （ADHD） by using resting-state functional magnetic resonance imaging （fMRI） degree centrality （DC） from the view of neuro-imaging.MethodsForty-five ADHD children were diagnosed at specialist clinic of Changzhou Children′s Hospital, Nantong University from June 2015 to December 2016, and they were divided into 3 groups according to their ages （children aged 7-8 years old, 9-10 years old and 11-12 years old, 15 children in each group） and received the resting-state fMRI scans.DC value was used to analyze fMRI data.Comparative ana-lysis was done pairwise between the three groups.ResultsCompared with 7-8 years old group, 9-10 years old group showed lower DC value in cerebellum posterior lobe （t=-4.36） and higher DC in inferior parietal lobe （t=-5.86）, and the differences were statistically significant （all P〈0.05, after correction）. Compared with 7-8 years old group, 11-12 years old group showed lower DC value in cerebellum posterior lobe （t=-4.99） and higher DC in left superior temporal gyrus （t=5.18） and superior frontal gyrus （t=4.58）, and the differences were statistically significant （all P〈0.05, after correction）. Compared with 9-10 years old group, 11-12 years old group showed lower DC value in inferior parietal lobe （t=-5.71） and higher DC value in left superior temporal gyrus （t=5.05） and superior frontal gyrus （t=4.36）, and all the differences were statistically significant （all P〈0.05, after correction）.ConclusionChildren with ADHD at different ages had different characteristics of brain regions of fMRI.It can offer objective evidence for early cognitive intervention of children with ADHD at different ages.

关 键 词：注意缺陷多动障碍 功能磁共振 度中心度 儿童认知 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.94[医药卫生—诊断学]