声带黏膜组织工程的研究进展  

Development of tissue engineered vocal fold mucosa

作　　者：何长顶 邵骏 

机构地区：[1]复旦大学附属眼耳鼻喉科医院耳鼻喉科,上海200031

出　　处：《中国眼耳鼻喉科杂志》2018年第1期64-67,共4页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘　　要：声带是喉部具有独特分层结构和多元基质的软性组织,负责发声功能。这种精细的结构很容易受到环境和医源性因素的损伤,造成声带组织结构发生变化,导致声功能损害,影响患者的日常生活。目前,针对声带瘢痕和声带纤维化仍没有有效的治疗方法,但移植性、生物组织工程声带黏膜可能解决这个问题。本文就近些年声带黏膜组织工程技术的发展进行综述。The vocal folds （VF） are laryngeal connective tissues with complex matrix composition that provide the viscoelastic mechanical properties required for voice production and respiration. And it is particularly prone to scarring resulting from mechanical damage due to voice abuse or to other causes. Nowadays, since little method can currently be dune to treat VF Scarring and Fibrosis, alternate treatments are needed. One alternative approach is the use of a teansplantable, bioengineered VF nycisa to restore normal tissue geometry and physiology. This paper summarizes the lastest research progress in the tissue engineer of vocal fold mucosa.

关 键 词：声带黏膜 组织工程 种子细胞 网架 细胞外基质 

分 类 号：R318[医药卫生—生物医学工程]