N-9 Alkylation of purines via light-promoted and metal-free radical relay  

作　　者：Runze Mao Lifeng Sun Yong-Shi Wang Min-Min Zhou De-Cai Xiong Qin Li Xin-Shan Ye 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University

出　　处：《Chinese Chemical Letters》2018年第1期61-64,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos. 21232002. 21572012);Beijing Natural Science Foundation (No. 7152085)

摘　　要：A metal-free and light-promoted approach to the synthesis of N-9 alkylated purine nucleoside derivatives, via a CF3 radical triggered radical relay pathway, has been developed. Purine nucleoside derivatives were prepared regioselectively in good to high yields. Photosensitizers and metals are free in this transformation. Visible light or even sunlight can be used as the source of light for the reactions.A metal-free and light-promoted approach to the synthesis of N-9 alkylated purine nucleoside derivatives, via a CF3 radical triggered radical relay pathway, has been developed. Purine nucleoside derivatives were prepared regioselectively in good to high yields. Photosensitizers and metals are free in this transformation. Visible light or even sunlight can be used as the source of light for the reactions.

关 键 词：PhotochemistryAlkylation of purinesRegioselectivityMetal fleeCF3 radical 

分 类 号：O6[理学—化学]