Synthesis and anti-inflammatory activity of gold-nanoparticle bearing a dermatan sulfate disaccharide analog  

作　　者：Chengxiang Shang Chao Cai Cuixia Zhao Yuguo Du 

机构地区：[1]State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences [2]School of Chemistry and Chemical Engineering, Graduate University of Chinese Academy of Sciences [3]Key Lab of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China

出　　处：《Chinese Chemical Letters》2018年第1期81-83,共3页中国化学快报（英文版）

基　　金：supported in partial by the National Natural Science Foundation of China(Nos.21232002,21372254,21621064 and 21672255)

摘　　要：A dermatan sulfate （DS） repeating disaccharide analog, β-L-idopyranosiduronate-（1→3）-2-amino-2- deoxy-4,6-di-O-sulfo-β-D-galactopyranoside, has been convergently synthesized and successfully applied to prepare the GAG-functionalized gold glyconanoparticle. This new material exhibited good anti-inflammatory activity which was comparable to that of the drug ibuprofen incarrageenan-induced paw edema in a rat model.A dermatan sulfate （DS） repeating disaccharide analog, β-L-idopyranosiduronate-（1→3）-2-amino-2- deoxy-4,6-di-O-sulfo-β-D-galactopyranoside, has been convergently synthesized and successfully applied to prepare the GAG-functionalized gold glyconanoparticle. This new material exhibited good anti-inflammatory activity which was comparable to that of the drug ibuprofen incarrageenan-induced paw edema in a rat model.

关 键 词：L-lduronic acidGold glyconanoparticlesDermatan sulfate disaccharideAnti-inflammatoryCarbohydrates 

分 类 号：O6[理学—化学]