Synthesis and antiviral bioactivity of novel chalcone derivatives containing purine moiety  

作　　者：Yan-Jiao Wang Da-Gui Zhou Fang-Cheng He Ji-Xiang Chen Yong-Zhong Chen Xiu-Hai Gan De-Yu Hu Bao-An Song 

机构地区：[1]State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University

出　　处：《Chinese Chemical Letters》2018年第1期127-130,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos. 21562013 and 21362004);Subsidy Project for Outstanding Key Laboratory of Guizhou Province in China(No. 20154004);the Provincial University Cooperation Plan of Guizhou Province in China(No. 20147001);Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan

摘　　要：A series of novel chalcone derivatives containing purine moiety was designed and synthesized, and their antiviral activities against cucumber mosaic virus （CMV） and tobacco mosaic virus （TMV） were evaluated in vivo. Bioactivity assays indicated that some compounds showed good antiviral activities against CMV and TMV. It is worth mentioning that compounds 30, 3s, 3w, and 3x exhibited excellent curative activity against CMV, with ECso values of 301.1 μg/mL, 315.7 μg/mL, 282.3 μg/mL, 230.5 μg/mL, respectively, which were better than that of Dufulin （373.7 μg/mL） and Ribavirin （726.3 μg/mL）. In addition, the fluorescence spectroscopy experiment results showed that compound 3o showed strong combining capacity to tobacco mosaic virus coat orotein.A series of novel chalcone derivatives containing purine moiety was designed and synthesized, and their antiviral activities against cucumber mosaic virus （CMV） and tobacco mosaic virus （TMV） were evaluated in vivo. Bioactivity assays indicated that some compounds showed good antiviral activities against CMV and TMV. It is worth mentioning that compounds 30, 3s, 3w, and 3x exhibited excellent curative activity against CMV, with ECso values of 301.1 μg/mL, 315.7 μg/mL, 282.3 μg/mL, 230.5 μg/mL, respectively, which were better than that of Dufulin （373.7 μg/mL） and Ribavirin （726.3 μg/mL）. In addition, the fluorescence spectroscopy experiment results showed that compound 3o showed strong combining capacity to tobacco mosaic virus coat orotein.

关 键 词：Chalcone derivatives6-Chloro-purineAntiviral activityCucumber mosaic virusTobacco mosaic virusInteraction mechanisms 

分 类 号：O6[理学—化学]