Highly efficient and chemoselective direct aldol reaction of acyldiazomethane with aldehydes promoted by MgI_2 etherate  

作　　者：Weipeng Qi Xiaoqiang Xie Tengjiang Zhong Xingxian Zhang 

机构地区：[1]College of Pharmaceutical Sciences, Zhejiang University of Technology

出　　处：《Chinese Chemical Letters》2018年第1期194-196,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (Nos. 21372203 and 21272076)for the financial support

摘　　要：Direct aldol condensation of various aromatic, heteroaromatic, α,β-unsaturated aldehydes and aliphatic aldehydes with acyldiazomethane was realized using Mgl2 etherate （Mgl2.（Et2O）n） as a promoter in the presence of diisopropyl amine （DIPEA） in excellent yields in a short time under mild conditions with high chemoselectivity. Iodide counterion, and a non-coordinating less ploar reaction media （i.e., CH2C12） are among the critical factors for this unique reactivity.Direct aldol condensation of various aromatic, heteroaromatic, α,β-unsaturated aldehydes and aliphatic aldehydes with acyldiazomethane was realized using Mgl2 etherate （Mgl2.（Et2O）n） as a promoter in the presence of diisopropyl amine （DIPEA） in excellent yields in a short time under mild conditions with high chemoselectivity. Iodide counterion, and a non-coordinating less ploar reaction media （i.e., CH2C12） are among the critical factors for this unique reactivity.

关 键 词：ChemoselectiveAldehydeAcyldiazomethaneDirect aldol reactionMgl2 etherate 

分 类 号：O6[理学—化学]