Magnetic nanoparticles supported cinchona alkaloids for asymmetric Michael addition reaction of 1,3-dicarbonyls and maleimides  

作　　者：Shi-Xuan Cao Jia-Xi Wang Zheng-Jie He 

机构地区：[1]School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, China [2]The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China [3]Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China

出　　处：《Chinese Chemical Letters》2018年第1期201-204,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(No. 21472096)

摘　　要：Magnetic nanoparticles Fe3O4@SiO2 supported cinchona alkaloids （quinine and quinidine） were successfully synthesized as magnetically recoverable organocatalysts and characterized by FT-IR, XPS, SEM measurements, and elemental analysis. Their catalytic activity and stereoselectivity were preliminarily evaluated in the asymmetric Michael addition reaction of 1,3-dicarbonyls and maleimides. The supported quinine catalyst exhibited good catalytic efficiency and modest to high enantioselectivity. The magnetic recoverabiliW and recyclability of the catalyst were also examined.Magnetic nanoparticles Fe3O4@SiO2 supported cinchona alkaloids （quinine and quinidine） were successfully synthesized as magnetically recoverable organocatalysts and characterized by FT-IR, XPS, SEM measurements, and elemental analysis. Their catalytic activity and stereoselectivity were preliminarily evaluated in the asymmetric Michael addition reaction of 1,3-dicarbonyls and maleimides. The supported quinine catalyst exhibited good catalytic efficiency and modest to high enantioselectivity. The magnetic recoverabiliW and recyclability of the catalyst were also examined.

关 键 词：Magnetic nanoparticlesCinchona alkaloidsImmobilizationMichael additionAsymmetric catalysis 

分 类 号：O6[理学—化学]