婴幼儿胼胝体髓鞘化磁共振水分数随龄性变化  

Age-related MR myelin water faction trajectories in corpus callosum of infants

作　　者：崔尊社 陈亚娣[1] 李建凯[1] 靳刚[1] 王国锋 

机构地区：[1]西安市华山中心医院放射科,陕西西安710043

出　　处：《实用放射学杂志》2018年第1期92-93,104,共3页Journal of Practical Radiology

摘　　要：目的 明确婴幼儿胼胝体磁共振髓鞘水分数随龄性变化趋势.方法 连续征集100名健康0~2岁健康婴幼儿,纳入标准：生母无孕期并发症,无酗酒等嗜好,生产无缺氧等脑损伤发生,发育正常,经儿科神经内科医师进行临床评估无异常神经体征,无影响神经系统的全身性疾病,常规MR扫描脑实质未见异常.应用美国GE 1.5T磁共振成像仪,8通道头部射频线圈,采集全脑常规轴面T1WI、T2WI及矢状面T1WI,等体素全脑SPGR和SSFP序列扫描.将感兴趣区（ROI）分别置于胼胝体膝部（ROI1）、体部中央区（ROI2）及胼胝体压部（ROI3）.ROI的体积为（100 ± 20）mm3,提取计算各ROI髓鞘水分数,分析胼胝体不同分区髓鞘水分数随年龄增长变化趋势.结果 胼胝体膝部不同分区髓鞘水分数随年龄变化拟合曲线方程式分别为：膝部y=0.0681ln（x）-0.3306, R2=0.9558;体部y=0.0628ln（x）-0.2975,R2=0.9373;压部y=0.0575ln（x）-0.2652,R2=0.9234.结论 应用磁共振髓鞘水分数可以量化评估胼胝体髓鞘化过程.Objective To determine the trajectories of the myelin water faction of the corpus callosum of infants.Methods Continuous collection of 100 health 0-2 years old baby.Inclusion criteria are as follows：the birth mother with no complications during pregnancy, no drinking habits,without hypoxia brain injury occurs,and developing normally,conducted by the pediatric neurology doctors clinical evaluation no abnormal neurological signs,no systemic diseases involve the nervous system.Using GE 1.5T magnetic resonance imager, 8 channel head coil,T1WI,T2WI and sagittal T1WI were performed,and the whole brain SPGR and SSFP sequence were scanned. The region of interest（ROI）was placed in the genu of the corpus callosum（ROI1）,the central region of the body（ROI2）and splenium of corpus callosum（ROI3）.The volume of ROI was（100 ± 20）mm3,and the myelin water fraction was calculated.Results The trajectories curve equation of the myelin water faction of the genu,body and splenium of the corpus callosum are as follows respectively：genu y=0.068 1ln（x）-0.330 6,R2=0.955 8;body y=0.062 8ln（x）-0.297 5,R2=0.937 3;splenium y=0.057 5ln（x）-0.265 2,R2=0.923 4.Conclusion The application of magnetic resonance myelin water fraction can be used to quantitatively evaluate the myelin development process.

关 键 词：婴幼儿 胼胝体 磁共振成像 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R445.2[医药卫生—基础医学]