四川省绵阳市15~49岁育龄期妇女抗-HBs流行现状分析  

Seroprevalences of hepatitis B surface antibody among 15~49 childbearing-age women in Mianyang, Sichuan Province

作　　者：李文龙 刘小锦 刘婷婷 周晓婷 彭友悦 袁萍 王娟[2] 任涛[3] 王丽萍[4] 

机构地区：[1]四川大学华西公共卫生学院(华西第四医院),四川成都610041 [2]四川大学华西医院,四川成都610041 [3]绵阳市涪城区疾病预防控制中心,四川绵阳621000 [4]江油市疾病预防控制中心,四川绵阳621700

出　　处：《现代预防医学》2018年第2期243-246,254,共5页Modern Preventive Medicine

基　　金：十二五国家科技重大专项(NO.2012ZX10004-901)

摘　　要：目的了解四川省绵阳市15~49岁育龄期妇女的抗-HBs流行现状,为四川社区育龄期妇女乙肝防治管理模式的建立提供科学依据。方法 2014年12月-2015年12月,采用多阶段分层整群随机抽样方法,对四川省绵阳市105 606名育龄期妇女进行问卷调查和乙肝血清学检测。结果绵阳市15~49岁育龄期妇女抗-HBs阳性60 697人,抗-HBs阳性率为57.5%;抗-HBs阳性率随年龄增大而降低,20~24岁组妇女抗-HBs阳性率最高,为62.3%(7 847/12 589),25~29岁组抗-HBs阳性率最低,为54.5%(3 722/6 824);医务人员抗-HBs阳性率最高,为72.5%(980/1 351),农民抗-HBs阳性率最低,为53.9%(20 432/37 935);不同年龄组、职业、婚姻状况、民族、居住地区及有无乙肝疫苗接种史人群的抗-HBs阳性率差异均有统计学意义(P<0.05)。结论绵阳市15~49岁育龄期妇女抗-HBs阳性率较低,对HBV感染抵抗力不足,应及时制定与实施育龄期妇女乙肝疫苗加强免疫策略。Objective To understand the seroprevalences of hepatitis B surface antibody among 15 ~49 childbearing-age women in Mianyang, Sichuan Province, and to provide evidences for the establishment of hepatitis B prevention and control strategy for town/community among childbearing-age women in Sichuan Province. Methods From December 2014 to December 2015, a total of 105 606 childbearing-age women were selected through stratified cluster random sampling to conduct an interview with standard questionnaire and hepatitis B serological detection in Mianyang, Sichuan Province. Results Among the childbearing-age women surveyed, 60 697 were hepatitis B surface antibody positive（57.5%）. The positive rate of hepatitis B surface antibody was highest in childbearing-age women aged 20~24 （62.3%） and lowest in childbearing- age women aged 25-29 （54.5%）. The positive rate of hepatitis B surface antibody was highest in medical workers （72.5%） and lowest in farmers （53.9%）. The differences among the age, occupation, marital status, nationality, region, and the history of receiving hepatitis B immunization were all statistically significant （P〈0.05）. Conclusion The positive rate of hepatitis B surface antibody was 57.5% in childbearing-age women. The childbearing-age women were susceptible to hepatitis B infection. It is necessary to develop and implement hepatitis B immunization strategy for childbearing-age women.

关 键 词：乙型肝炎病毒 乙型肝炎病毒表面抗体 育龄期妇女 免疫策略 

分 类 号：R173[医药卫生—妇幼卫生保健]