中医药改善糖尿病肾病糖代谢紊乱的机制  

Mechanism Study on Traditional Chinese Medicine to Improve Diabetic Nephropathy Sugar Metabolic Disorder

作　　者：董彬[1] 王辉[1] 苌沛森 刘珮[1] 王静[1] 张志强[1] 

机构地区：[1]河南中医药大学,河南郑州450046

出　　处：《中医学报》2018年第1期62-66,共5页Acta Chinese Medicine

基　　金：河南中医药大学创新人才项目(2013XCXRC04);河南中医药大学研究生科研苗圃工程项目(MP2014-90)

摘　　要：中医药治疗糖尿病肾病(diabetic nephropathy,DN)还存在以下不足:首先,中医的辨证分型太多,各大家章法不一,缺乏严格的循证医学验证,以致没有权威的辨证分型及疗效判断标准;其次,相关实验研究缺乏中医特色,尚不能明确其作用机理,动物实验所采用的模型基本上照搬西医,研究缺少严格的科研设计,大部分实验都停留在观察现象和推测机制阶段,缺乏定量分析及各指标间相互关系的研究。在以后的研究中,应该进一步探讨DN的病因病机、临床分型及其论治方法,建立公认的基本证型及临床疗效判定标准。同时,建立具有中医特色的实验研究,并创立具有针对性的系列方药,多总结经方、验方,对疗效确切的经方、验方进行剂型改革,深入研究单味中药及复方的作用机理。There are still some deficiencies in treatment of diabetic nephropathy（ DN） with traditional Chinese medicine： First of all,there are too many syndromes in TCM being divided with different rules and regulations,and there is a lack of rigorous evidence-based medical verification. As a result,there is no authoritative judgment standard in syndrome differentiation and clinical efficacy. Second,there is a lack of the characteristics of traditional Chinese medicine the relevant experimental studies; hence its TCM mechanism of action cannot be clarified. The models used in animal experiments are basically the same copy as that in Western medical researches. There are lacks of rigorous scientific research design in experiments and most of them remain in the stage of observation and the speculation of mechanisms. There is a lack of quantitative analysis and the relationship exploration between the various indicators of the research. In future studies,we should further explore the etiology and pathogenesis of DN as well as establishing the clinical classification and treatment methods,the establishment of recognized syndromes and clinical efficacy criteria. At the same time,the establishment of experimental studies with Chinese characteristics and the creation of targeted series of prescription drugs should be done. More prescriptions with exact effect should be further studied. The action mechanism of single herbs should also be studied in-depth.

关 键 词：糖尿病肾病 糖代谢紊乱 中医药疗法 

分 类 号：R259.872[医药卫生—中西医结合]