银杏叶提取物治疗突发性耳聋气滞血瘀证临床研究  

Clinical Study on Ginkgo Biloba Extract in Treatment of Qi Stagnation and Blood Stasis Type of Sudden Deafness

作　　者：于玲 徐静[1] 

机构地区：[1]首都医科大学附属北京潞河医院,北京101149

出　　处：《中医学报》2018年第1期145-148,共4页Acta Chinese Medicine

基　　金：国家自然科学基金重点项目(81230020);北京市自然科学基金面上项目(7132177)

摘　　要：目的:观察银杏叶提取物治疗突发性耳聋气滞血瘀证的临床疗效。方法:将132例突发性耳聋气滞血瘀证患者随机分为对照组和治疗组,每组66例。对照组采用前列地尔+泼尼松治疗;治疗组采用前列地尔+泼尼松+银杏叶酊治疗。对两组患者听阈水平、临床疗效、中医证候积分和不良反应情况进行评价。结果:治疗组有效率为92.42%,明显高于对照组75.76%,差异有统计学意义(P<0.05)。与治疗前比较,两组患者中医证候积分均明显下降,差异均有统计学意义(P<0.05);两组患者所阈水平比较,治疗组低于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对突发性耳聋气滞血瘀证患者加用银杏叶提取物治疗,可显著提高临床疗效,缓解临床症状,促进患者听力的恢复,且不会增加不良反应的发生。Objective： To observe the clinical efficacy of ginkgo biloba extract（ GBE） in treatment of Qi stagnation and blood stasis type of sudden deafness. Methods： 132 patients were randomly divided into the control group and the treatment group,each of 66 cases. The control group took alprostadil and prednisone; the treatment group took alprostadil,prednisone and gingko biloba tincture. The changes of hearing threshold level,clinical symptoms,adverse reactions of two groups before and after treatment were compared,and clinical efficacy of two groups were evaluated. Results： The effective rate of treatment group was 92. 42%,significantly higher than 75. 76% of control group（ P〈0. 05）; Compared with pre-treatment,the TCM symptom scores of two groups significantly decreased after treatment（ P〈0. 05）,and the treatment group was higher than control group（ P〈0. 05）; There was no statistical difference in the incidence of adverse reactions between the two groups（ P〉0. 05）. Conclusion： GBE for treating patients with Qi stagnation and blood stasis type of sudden deafness can significantly improve clinical efficacy,relieve clinical symptoms,promote hearing recovery and not increase adverse reactions.

关 键 词：突发性耳聋 银杏叶提取物 气滞血瘀证 听阈水平 中医药治疗 中西医结合 

分 类 号：R276.164.43[医药卫生—中医五官科学]