非编码RNA在微囊藻毒素-LR致毒中作用的研究进展  

Review on role of non-coding RNA in microcystin-LR toxicity

作　　者：杨书[1] 杨飞[1] 冯湘玲 陈继华[1] 文聪 陈律[1] 

机构地区：[1]中南大学湘雅公共卫生学院,湖南长沙410008

出　　处：《环境与职业医学》2018年第1期83-88,共6页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金面上项目(编号:81773393;81472972);国家自然科学青年基金项目(编号:81502787);湖南省自然科学青年基金项目(编号:2016JJ3166);中国博士后科学基金特别资助(编号:2016T90766);中国博士后科学基金项目(编号:2015M572273)

摘　　要：微囊藻毒素-LR(microcystin-LR,MC-LR)是蓝藻产生的微囊藻毒素中毒性最强的一种,对生态环境和公共卫生安全造成严重威胁。现有的研究表明,MC-LR可通过抑制蛋白磷酸酶活性、诱导氧化应激以及DNA损伤发挥毒性作用,但其毒性机制尚未明确。非编码RNA(non-coding RNA,ncRNA)是一类不编码蛋白质的RNA分子,其在炎症、肿瘤的发生发展以及外源化学物致毒过程中发挥非常重要作用,近年来研究发现ncRNA参与MC-LR致毒过程。本综述关注了ncRNA在MC-LR致毒过程中的调控效应,为进一步研究MC-LR的毒性机制提供思路。Microcystin-LR （MC-LR） is one of the most toxic microcystins produced by cyanobacteria, posing a serious threat to ecological environment and public health. Previous studies have shown that MC-LR may cause toxicity by inhibiting protein phosphatase activity and inducing oxidative stress and DNA damage. However, the associated mechanism of its toxicity remains unclear. Noncoding RNA （ncRNA） is a class of RNA molecules that do not encode proteins, playing an important role in mediating inflammation, tumor genesis and development, and the toxicity of exogenous chemicals. Recent studies have shown that ncRNA is involved in the regulation of MC-LR toxicity. This paper reviewed the role of ncRNA in mediating MC-LR toxicity, aiming to provide an insight for further study on the mechanism of MC-LR toxicity.

关 键 词：微囊藻毒素-LR 非编码RNA 毒性 毒性机制 

分 类 号：R12[医药卫生—环境卫生学]