血清hs-CRP及VEGF水平对急性心肌梗死经皮冠状动脉介入治疗术后心血管事件的影响  

Effects of hs-CRP and VEGF on major adverse cardiovascular events in patients with acute myocardial infarction after percutaneous coronary intervention

作　　者：艾民[1] 颜昌福[1] 夏福纯[1] 周双陆[1] 贺剑[1] AI Min;YAN Changfu;XIA Fuchun;ZHOU Shuartglu;HE Jian(Pangang General Hospital of Kunming University of Science and Technology, Panzhihua 617023, China)

机构地区：[1]昆明理工大学附属攀钢集团总医院,四川攀枝花617023

出　　处：《山东医药》2018年第1期16-18,共3页Shandong Medical Journal

基　　金：四川省医学科研课题(S16046);四川省卫生和计划生育委员会科研课题(150097)

摘　　要：目的探讨血清高敏C反应蛋白(hs-CRP)及血管内皮生长因子(VEGF)对急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后主要心血管不良事件(MACE)的影响。方法选择AMI行PCI术后患者116例,根据术后是否发生MACE随机分为MACE组20例,非MACE(NMACE)组96例,分析术前,术后1 h、24 h及7 d血清hsCRP及VEGF水平。结果术后1 h、24 h、7 d,MACE组血清hs-CRP分别为(5.79±1.13)、(6.87±1.42)、(3.51±0.89)mg/L,VEGF分别为(167.8±49.8)、(146.8±43.9)、(121.5±29.6)pg/m L;NMACE组血清hs-CRP分别为(4.57±1.09)、(5.38±1.21)、(2.67±0.58)mg/L,VEGF分别为(145.7±40.3)、(115.6±39.7)、(95.7±21.7)pg/m L,两组不同时间点血清hs-CRP、VEGF比较差异均有统计学意义(P均<0.05)。结论血清hs-CRP及VEGF水平对预测AMI患者PCI术后MACE具有一定的临床价值。Objective To explore effects of serum high-sensitivity C-reactive protein（ hs-CRP） and vascular endothelial growth factor（ VEGF） on the major adverse cardiovascular events（ MACE） in patients with acute myocardial infarction（ AMI） after percutaneous coronary intervention（ PCI）. Methods Totally 116 patients with AMI were treated by PCI. According to the occurrence of MACE after PCI,the patients were divided into the MACE group of 20 cases and nonMACE（ NMACE） group of 96 cases. We analyzed the levels of hs-CRP and VEGF in patients before PCI,and at 1 h,24 h,and 7 d after PCI. Results At 1 h,24 h,and 7 d after PCI,the serum hs-CRP levels were（ 5. 79 ± 1. 13）,（ 6. 87 ±1. 42）,and（ 3. 51 ± 0. 89） mg/L in the MACE group,and the serum VEGF levels were（ 167. 8 ± 49. 8）,（ 146. 8 ±43. 9）,and（ 121. 5 ± 29. 6） pg/m L,respectively; the serum levels of hs-CRP in the NMACE group were（ 4. 57 ± 1. 09）,（ 5. 38 ± 1. 21）,and（ 2. 67 ± 0. 58） mg/L,and the serum hs-CRP levels were（ 145. 7 ± 40. 3）,（ 115. 6 ± 39. 7）,and（ 95. 7 ± 21. 7） pg/m L,respectively. Significant differences were found at different time points between these two groups（ all P〈0. 05）. Conclusion The serum hs-CRP and VEGF levels have some clinical value in predicting the occurrence of MACE in patients with AMI after PCI.

关 键 词：急性心肌梗死 经皮冠状动脉介入治疗 C反应蛋白质 血管内皮生长因子 

分 类 号：R541.4[医药卫生—心血管疾病]