新疆汉族、维吾尔族血小板参数与冠状动脉狭窄程度的相关性研究  

Correlation between platelet indices and degree of coronary artery stenosis in Han and Uygur ethnics in Xinjiang

作　　者：盖敏涛 刘芬 谢翔 杨毅宁[1,2] 马翔 李晓梅[1,2] 付真彦 黄莺[1,2] 陈邦党 陈小翠[1] 马依彤 

机构地区：[1]新疆医科大学第一附属医院临床医学研究院新疆心血管疾病研究重点实验室,乌鲁木齐830011 [2]新疆医科大学第一附属医院心脏中心冠心病科

出　　处：《临床心血管病杂志》2018年第1期30-34,共5页Journal of Clinical Cardiology

基　　金：长江学者和创新团队发展计划(No:IRT17R93)

摘　　要：目的:探讨新疆汉族、维吾尔族(维族)血小板参数与冠状动脉(冠脉)狭窄程度的关系。方法:收集2014-09-2015-09在新疆医科大学第一附属医院心导管室进行冠脉造影的汉族、维族患者的临床数据,根据Gensini评分分为高评分组(Gensini评分≥40)和低评分组(Gensini评分<40),比较不同民族患者血小板参数的差异,通过Logistic回归分析评价血小板参数与Gensini评分的相关性。结果:一共纳入3 921例研究对象,汉族2 835例,其中高评分组963例、低评分组1 872例;维族1 086例,其中高评分组446例,低评分组640例。汉族患者血小板分布宽度(PDW)显著高于维族[(14.96±0.05)%︰(14.68±0.09)%,P<0.05];汉族患者血小板(PLT)均值显著低于维族[(217.07±1.12)×109/L︰(244.84±2.27)×109/L,P<0.05];两民族间平均血小板体积(MPV)并无显著差异。血小板参数与Gensini评分散点图以及线性回归分析结果显示,在汉族中,PLT与Gensini评分显著正相关(r=0.06,P<0.05);在维族中,PDW与Gensini评分显著负相关(r=-0.09,P<0.05)。调整危险因素后,二元Logistic回归分析结果显示,汉族PLT是冠脉狭窄程度高评分的危险因素(OR=1.02,95%CI:1.01~1.03,P<0.05);维族PDW是冠脉狭窄程度高评分的保护因素(OR=0.95,95%CI:0.91~0.98,P<0.05)。结论:新疆汉族、维族血小板参数存在差异,在汉族人群中,PLT与冠脉狭窄程度显著正相关,是冠脉狭窄的危险因素;在维族人群中,PDW与冠脉狭窄存在负相关性,是冠脉狭窄的保护因素。Objective：To explore the relationship between platelet indices and degree of coronary artery stenosis in Han and Uygur ethnics in Xinjiang.Method：The clinical data of Han Uigur subjects who underwent coronary angiography from September 2014 to September 2015 in the First Affiliated Hospital of Xinjiang Medical University was collected.All subjects were divided into high score group（Gensini score≥40）and low score group（Gensini score40）.Platelet indices were compared between Han and Uygur ethnics.Logistic regression analysis was used to analyze the relationship between platelet indices and Gensini score.Result：A total of 3 921 cases were included in the study,of whom 2 835 were Han population including 963 cases in high score group and 1 872 in low score group,and 1 086 were Uygur population including 446 in high score group and 640 in low score group.Platelet distribution width（PDW）was significantly higher in Han than that in Uygur[（14.96±0.05）%∶（14.68±0.09）%,P〈0.05];Platelet（PLT）was significantly lower in Han than that in Uygur[（217.07±1.12）×10^9/L∶（244.84±2.27）×10^9/L,P〈0.05].There was no significant difference in MPV between the two ethnics.The results of platelet parameters and Gensini score scatter diagram and linear regression analysis showed that PLT was significant positive correlated with Gensini score in Han patients（r=0.06,P〈0.05）,while PDW was significant negative with Gensini score in Uygur patients（r=-0.09,P〈0.05）.After adjusting risk factors,Logistic regression analysis showed that PLT was a risk factor of coronary stenosis in Han nationality（OR=1.02,95%CI：1.01-1.03,P〈0.05）,and PDW was a protective factor of coronary stenosis in Uygur nationality（OR=0.95,95%CI：0.91-0.98,P〈0.05）.Conclusion：Platelet indices are statistical different between Han and Uygur in Xinjiang.PLT is positively correlated with degree of coronary stenosis in Han nationality and is a risk factor of coronary artery stenosis.PDW is negatively correla

关 键 词：血小板参数 GENSINI评分 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]