小剂量丙戊酸钠和小剂量安定防治小儿热性惊厥的疗效及安全性比较  

Comparison of the efficacy and safety of small dose valproate and small dose of diazepam in the prevention and treatment of febrile convulsion in children

作　　者：陈伊洁 

机构地区：[1]广东省汕头市潮阳区人民医院,广东汕头515100

出　　处：《中国医药科学》2018年第2期36-38,共3页China Medicine And Pharmacy

摘　　要：目的探究小剂量丙戊酸钠和小剂量安定防治小儿热性惊厥的疗效及安全性比较。方法选取我院2015年1月～2017年5月儿科收治的80例小儿热性惊厥患儿,随机分为观察组及对照组,每组各40例。对照组患儿给予小剂量安定治疗,观察组患儿给予小剂量丙戊酸钠治疗,比较两组患儿治疗效果及安全性。结果经治疗后,观察组和对照组患儿的治疗有效率分别为92.5%和70.0%,观察组明显高于对照组,差异有统计学意义(χ2=6.646,P<0.05);观察组患儿止惊时间(12.51±3.45)min和退热时间(11.56±2.47)h均较对照组患儿明显缩短[(17.28±4.12)min,(16.41±3.65)h],差异均有统计学意义(t=5.614,6.960,P<0.05);观察组患儿不良反应发生率(7.5%)和复发率(5.0%)明显低于对照组(30.0%,20.0%),差异均有统计学意义(χ2=6.646,4.114,P<0.05)。结论作为小儿热性惊厥的治疗药物,丙戊酸钠较安定临床疗效显著,可快速缓解患儿症状,促进恢复,显著减少不良反应发生,复发率低,安全可靠,值得临床推广采用。Objective To investigate the efficacy and safety of small dose valproate and small dose of diazepam in the prevention and treatment of febrile convulsion in children. Methods Eighty children with febrile convulsions in pediatrics from January 2015 to May 2017 were randomly divided into the observation group and the control group,with 40 cases in each group.The children in the control group were treated with small dose of diazepam,and the children in the observation group were treated with a small dose of sodium valproate,and the efficacy and safety of the two groups were compared. Results After treatment,the effective rates of the observation group and the control group were 92.5% and 70.0%,respectively.The difference between the observation group and the control group was statistically significant （χ^2=6.646,P 〈 0.05）.The time of panic arrest （12.51±3.45） min and antipyretic time （11.56±2.47）h in the observation group were significantly shorter than those in the control group [（17.28±4.12）min,（16.41±3.65）h],the differences were statistically significant （t=5.614,6.960,P 〈 0.05）.The incidence of adverse reactions （7.5%） and recurrence rate （5.0%） in the observation group were significantly lower than lhose in the control group （30.0%,20.0%）,and the difference was statistically signifieant （χ^2=6.646,4.114,P 〈 0.05）. Conclusion As a therapeutic drug for febrile convulsion in children,sodium valproate is more effective than diazepam in clinical treatment.It can relieve symptoms and promote recovery,reduce the incidence of adverse reactions,and reduce the recurrence rate.It is safe and reliable,and is worthy of clinical promotion.

关 键 词：丙戊酸钠 安定 热性惊厥 安全性 

分 类 号：R720.597[医药卫生—急诊医学]