两种结合雌激素对围绝经期妇女雌激素水平及脂代谢影响多中心临床研究  

Multicenter clinical study on the effect of two kinds of conjugated estrogen on estrogen level and lipid metabolism in perimenopausal women

作　　者：左宏玲 林守清[1] 高晓黎[3] 郑淑蓉[4] 张震宇[5] 刘宏伟[6] 王淑玉 孙爱军[1] 

机构地区：[1]中国医学科学院北京协和医科大学北京协和医院妇产科,北京100730 [2]河北医科大学第二医院妇产科,河北石家庄050000 [3]新疆医科大学药学院,新疆乌鲁木齐830001 [4]北京大学第一医院妇产科,北京100034 [5]首都医科大学朝阳医院妇产科,北京100020 [6]四川大学华西第二医院妇产科,四川成都610041 [7]江苏省人民医院妇产科,江苏南京210029

出　　处：《中国实用妇科与产科杂志》2018年第1期84-88,共5页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家自然科学基金(11471024)

摘　　要：目的比较国产结合雌激素片与进口结合雌激素片对围绝经期妇女雌激素水平及脂代谢的影响。方法2003年9月至2005年6月,就诊于北京协和医院等5家医院的223例受试者被随机分到试验组(国产结合雌激素片)112例和对照组(进口结合雌激素片)111例。连续序贯方案治疗4个周期。用药前后测定血清中雌二醇(E2)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)与三酰甘油(TG)水平。结果治疗后E2水平试验组与对照组均升高,组内比较均P<0.05;组间比较P>0.05。治疗后血脂水平HDL-C、TG显著升高,LDL-C显著降低,组内比较P均<0.05;TC对照组与试验组均降低,对照组组内变化达到统计学差异,P<0.05;试验组未达到统计学差异,P>0.05。两组间各血脂指标上升或下降的差异均无统计学意义(P>0.05)。结论国产结合雌激素可改善脂代谢紊乱情况,升高E_2水平,非劣效于进口结合雌激素。Objective To compare the effects of domestic conjugated estrogen tablets （test group）with imported estrogen tablets （control group）on estrogen level and lipid metabolism in perimenopausal women.Methods The trial was conducted between September 2003 and June 2005.Totally 223 postmenopausal women that from 5 hospitals including Peking Union Medical College Hospital were randomly assigned into two groups： 112 cases in the test group and 111 cases in the control group. Drugs were given in a continuous sequential pattern for 4 cycles. The serum estradiol （E2）, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, total cholesterol （TC） and triglyceride（TG）were measured before and after the use of drugs.Results The E2 level after treatment increased in both the study group and the control group ： in- group comparison ： P〈0.05, comparison between groups P〉0.05.Serum lipid level after treatment： HDL-C increased in both the study group and the control group：in-group comparison： P〈0.05, comparison between groups P〉0.05; LDL-C decreased in both the study group and the control group, in-group comparison ： P〉0.05, comparison between groups ： P〉0.05.TC decreased in both the study group and the control group, and the change in the control group was statistically significant, P〈O.OS.comparison between groups： P〉0.05.TG increased in study group and the control group, in-group was comparison： P〈0.05, comparison between groups：P〉0.05. Conclusion The domestic estrogen can improve lipid metabolism and increase the E2 level in menopausal women significantly, and the effect is not inferior to that of the imported estrogen.

关 键 词：围绝经期综合征 激素替代治疗 结合雌激素 雌二醇 脂代谢 

分 类 号：R711.75[医药卫生—妇产科学]