手足口病患儿血清神经元特异性烯醇化酶及儿茶酚胺水平的临床意义  

Clinical significance of serum neuron specific enolase and catecholamine levels in children with hand,foot and mouth disease

作　　者：海元平 崔兰 李虹艾 李帮涛 黄婷[1] 向伟[1] 

机构地区：[1]海南省妇幼保健院(海南省儿童医院),海南海口570206

出　　处：《中国儿童保健杂志》2018年第2期196-198,共3页Chinese Journal of Child Health Care

基　　金：海南省卫生计生行业科研项目(琼卫2012ZD-03)

摘　　要：目的研究手足口病(HFMD)患儿血清神经元特异性烯醇化酶(NSE)及儿茶酚胺(CA)水平对重症手足口病的诊断价值,为临床上评估手足口病病情严重程度提供参考指标。方法研究对象为2014年1月-2015年12月在海南省妇幼保健院住院的110例手足口病患儿病例资料,按照卫生部颁发的手足口病诊疗指南(2010年版)分为轻症组(44例)、重症重型组(44例)、重症危重型组(22例)。入院时检测患儿血清NSE、CA水平,分析其水平在轻症与重症重型、重症重型与重症危重型之间的差异及其水平与手足口病病情严重程度的相关性。结果 1)重症重型组的NSE和肾上腺素(E)、去甲肾上腺素(NE)水平均明显高于轻症组,差异有统计学意义(P<0.05)。2)重症危重型组的NSE和E、NE、多巴胺(DA)水平均明显高于重症重型组,差异有统计学意义(P<0.05)。3)NSE、E、NE、DA水平与患儿手足口病病情严重程度均呈正相关(r=0.366,0.590,0.425,0.345,P均<0.05)。结论手足口病患儿的NSE和NE水平可随病情的进展而升高。NSE和NE可作为评估手足口病病情严重程度的参考指标。Objective To research the diagnostic value of serum neuron specific enolase （NSE） and catecholamine （CA） levels to severe hand foot mouth disease （HFMD） in children,and to provide reference for clinical evaluation of HFMD severity. Methods Totally 110 HFMD childen hospitalized in the Maternal and Child Health Care Hospital of Hainan Province from January 2014 to December 2015 were enrolled in this study.According to the Guide for the Diagnosis and Treatment of HFMD established in 2010 by the ministry of health,110 HFMD children were divided into mild group （44 cases）,severe severe group （44 cases） and critical severe group （22 cases）.The levels of NSE and CA were tested and compared among three groups.And the relationship between the levels of NSE,CA and the severity of HFMD was analyzed. Results 1）The levels of NSE and epinephrine（E）,dopaminel （NE） in severe group were significantly higher than those in the mild group （P〈0.05）.2） The levels of NSE and E,NE,DA in critical severe group were significantly higher than those in the severe severe group （P〈0.05）.3）The levels of NSE,E,NE,DA levels were positively related to the severity of HFMD （r=0.366,0.590,0.425,0.345,all P〈0.05）. Conclusion The levels of NSE and NE would increase with the disease progressing.And the levels of NSE and NE can be used as a reference indicator to assess the severity of HFMD.

关 键 词：手足口病 重症 神经元特异性烯醇化酶 儿茶酚胺 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健]