石英晶体微天平传感器及其在生物检测中应用的研究进展  

Progress in Quartz Crystal Microbalance and Its Application in Biological Detection

作　　者：姜鹏飞 杨鸿成 季晨阳 陈柱 聂立波 Jiang Pengfei;Yang Hongcheng;Ji Chenyang;Chen Zhu;Nie Libo(College of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007)

机构地区：[1]湖南工业大学生命科学与化学学院,株洲412007

出　　处：《化学通报》2018年第2期129-133,共5页Chemistry

基　　金：湖南省自然科学基金项目(2016JJ3053);湖南省大学生研究性学习和创新性实验计划项目(201711535035)资助

摘　　要：石英晶体微天平(Quartz crystal microbalance,QCM)是一种具有灵敏度高、免标记、可实时在线检测等优点的重要分析工具。在生物检测领域,QCM与多种信号放大方法相结合,广泛应用于对生物分子的高灵敏检测。新型耗散型QCM(QCM-D)通过对薄膜厚度、粘弹性等的研究,主要用于考察生物分子的吸附分离、构型变化等微观过程。本文主要阐述了QCM及QCM-D生物传感器的构建及其在DNA、蛋白质、细胞和微生物检测中的研究进展。Quartz crystal microbalance （QCM） is a significant analytical tool which has the advantages of high sensitivity, label-free and real-time detection. In the field of biological detection, QCM combining with signal amplification methods is widely used in ultrasensitive detection of biomolecules. The novel QCM with dissipation （QCM-D） is mainly used to investigate the microscopic processes such as adsorption/desorption and configuration change of biomoleeules by studying the thickness and viscoelasticity of the thin film. This paper reviewed the construction of QCM and QCM-D biosensors as well as their research progress in the detection of DNA, protein, cell and microorganism.

关 键 词：石英晶体微天平 生物检测 生物传感器 

分 类 号：TH715.11[机械工程—测试计量技术及仪器] TP212[机械工程—仪器科学与技术]