载柚皮素聚乳酸微球的制备、表征及释药性能研究  

Preparation,characterization and drug release properties of naringenin polylactic acid nanoparticles

作　　者：王斌[1,2] 王慧芳 张轶胜[1,2] 魏丽乔 许并社 

机构地区：[1]太原理工大学新材料界面科学与工程教育部重点实验室,山西太原030024 [2]太原理工大学新材料工程技术研究中心,山西太原030024

出　　处：《应用化工》2018年第1期52-55,58,共5页Applied Chemical Industry

基　　金：国家青年科学基金资助项目(51703152);山西省自然科学基金资助项目(201701D121044;201701D121030);山西省青年科技研究基金(2015021080;2012021008-4);山西省回国留学人员科研资助项目(2015-033)

摘　　要：采用改良的溶剂挥发法,将柚皮素制备成载柚皮素聚乳酸微球;并采用扫描电镜(SEM)、红外光谱(IR)、动态光散射粒度仪(DLS)、紫外可见分光光度计对微球的形貌、组成、载药性能和缓释性能等进行了表征测试。结果表明,优化工艺制得的载药微球呈圆整球形,粒径分布均匀,分布在100~200 nm之间,载药量为22.3%,包封率为64.7%,且在人工模拟体外环境下具有良好的缓释效果。该载药聚乳酸微球有望提高柚皮素的生物可利用度和溶解性,在生物医药领域具有潜在的应用前景。Naringenin-loaded polylactic acid nanoparticles were prepared by modified solvent evaporation method. Moreover,the structure,composition,drug loading,encapsulation efficiency and release properties of nanoparticles were characterized by scanning electron microscopy（ SEM）,infrared spectroscopy（ IR）,dynamic light scattering particle size analyzer（ DLS） and UV-Vis spectrophotometer. The results showed that the nanoparticles had uniform particle size distribution between 100 ~ 200 nm and good sustained-release effect,the drug loading rate was 22. 3%,the entrapment rate was 64. 7%. The drug-loaded polylactic acid nanoparticles are expected to improve the bioavailability and solubility of naringenin and have potential applications in the biomedical field.

关 键 词：柚皮素 聚乳酸 微球 缓释性能 

分 类 号：TQ326.9[化学工程—合成树脂塑料工业] TQ460