响应面法优化壳聚糖席夫碱合成工艺  

Application of response surface methodology in process optimization for chitosan Schiff's base

作　　者：郭睿[1] 郭煜 宋博 马兰 土瑞香 王映月[1] 

机构地区：[1]陕西科技大学教育部轻化工助剂化学与技术重点实验室,陕西西安710021

出　　处：《应用化工》2018年第1期100-105,共6页Applied Chemical Industry

基　　金：陕西省教育厅服务地方专项计划项目(15JF011);陕西省工业科技攻关项目(2016GY-146)

摘　　要：利用乙醇为溶剂,以壳聚糖和苯甲醛为原料,合成了苯甲醛壳聚糖席夫碱(B-CTS)。考察反应温度、苯甲醛用量、反应时间、pH值对产物缩合率的影响,使用响应面分析法对合成工艺进行优化。结果表明,最佳工艺条件为:反应温度70℃,pH=6,苯甲醛用量1.30 g,反应时间4 h。此工艺条件下,产物缩合率92.93%。建立的B-CTS缩合率二次回归方程,能有效地预测实验结果。Using ethanol as solvent,chitosan benzaldehyde Schiff＇s base（ B-CTS） was performed by the reaction between the 2-amino group of glucosamine residue of chitosan with benzaldehyde. The condensation rate was influenced by the reaction temperature,the dosage of benzaldehyde,the reaction time,pH value and solvent amount. Selected the significant effect on the condensation rate by single-factor experiment,the B-CTS process parameters was optimized by Box-Behnken experimental designs in response surface methodology. By using Box-Behnken experimental designs in response surface methodology,the optimum condition is： the reaction temperature 70 ℃,pH value = 6,the dosage of benzaldehyde 1. 30 g,the reaction time 4 h. Under these optimum conditions,the condensation rate was 92. 93%. Meanwhile,the quadratic regression equation was established and can predict the experimental results effectively.

关 键 词：壳聚糖 席夫碱 氨基保护 响应面法 优化 模型 聚合物 

分 类 号：TQ281[化学工程—有机化工] TQ314.1