温经化瘀汤联合输卵管介入再通术治疗寒凝瘀阻型输卵管炎性不孕症的临床效果  

Effect of Traditional Chinese Medicine Combined with Radiation Intervention on Clinical Efficacy and Inflammatory Factors in Patients with Tubal Infertility of Cold Coagulation Stasis Type

作　　者：王学静[1] 王泽鑫[1] 李建明[1] 田子英[1] 高同锁[2] 

机构地区：[1]内蒙古医科大学附属医院体检中心,呼和浩特010050 [2]内蒙古医科大学附属医院介入科,呼和浩特010050

出　　处：《临床误诊误治》2018年第1期89-92,共4页Clinical Misdiagnosis & Mistherapy

基　　金：内蒙古自治区教育厅自然科学基金项目(NJZY104)

摘　　要：目的探讨温经化瘀汤联合输卵管介入再通术治疗寒凝瘀阻型输卵管炎性不孕症的临床效果以及对白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平的影响。方法选择我院2014年1月—2015年11月收治的寒凝瘀阻型输卵管炎性不孕症100例,根据治疗方法的不同分为研究组和对照组各50例。两组均给予输卵管介入再通术疏通输卵管和抗炎等治疗,研究组在此基础上加用温经化瘀汤水煎服,1个月经周期为1个疗程,共6个疗程。观察1年后两组临床疗效,治疗前后中医症状积分及IL-6和TNF-α水平变化。结果至研究节点,研究组总有效率为98.0%(49/50),对照组总有效率为86%(43/50),差异有统计学意义(P=0.000)。治疗前组间比较两组患者下腹胀痛、白带、输卵管畅通度、舌脉积分和中医症状总积分均无统计学差异(P>0.05)。治疗后组间比较,研究组患者下腹胀痛、白带、输卵管畅通度、舌脉积分和中医症状总积分显著低于对照组(P<0.05)。两组患者治疗前IL-6和TNF-α比较差异均无统计学意义(P>0.05),治疗后研究组IL-6和TNF-α均显著低于对照组(P<0.05)。结论温经化瘀汤联合输卵管介入再通术治疗寒凝瘀阻型输卵管炎性不孕症有助于提高临床效果,并可降低炎性因子水平。Objective To investigate the clinical effect of traditional Chinese medicine combined with radiation inter-vention on clinical efficacy and inflammatory factors in patients with tubal infertility. Methods From January 2014 to Novem-ber 2015, 100 patients with tubal infertility in our hospital were studied and were randomly divided into the study group and the control group, and 50 cases were in each group. Radiation intervention to clear the fallopian tube and anti-infection treat-ment were given to the both groups. Moreover, oral administration of Wen Jing Hua Yu Tang was given to the study group as well. The primary outcomes were clinical curative effect, TCM symptom score, IL-6 and TNF-a. Results In the study group, 28 cases were cured, 21 cases were effective, 1 cases were invalid; while in the control group, 18 cases were cured,25 cases were effective, 7 cases were invalid; the difference was statistically significant （P =0. 000） . Before treatment, there were no statistically significant differences in abdominal distension pain, leucorrhea, fallopian tube unobstructed degree,tongue pulse and TCM symptom scores between the two groups （P〉0.05）. However, when compared with the control group after treatment, the scores of abdominal distension pain, leucorrhea, fallopian tube unobstructed degree, tongue pulse and TCM symptoms of the study group were significantly lower than those of the control group （F 〈0. 05）. There was no signifi-cant difference in IL-6 and TNF-a between the two groups before treatment （P 〉0.05）. After treatment, the levels of IL-6 and TNF-a in the study group were significantly lower than those in the control group （P 〈 0 . 05）. Conclusion Traditional Chinese medicine combined with radiotherapy is helpful to reduce the inflammatory reaction and improve the clinical efficacy in patients with tubal infertility.

关 键 词：不育 女(雌性) 输卵管炎 放射摄影术 介入性 医学 中国传统 白细胞介素6 肿瘤坏死因子α 

分 类 号：R271.14[医药卫生—中医妇科学]