聚合物胶束载药系统的研究进展  

Research Process of Polymeric Micelles for Drug Delivery

作　　者：宗蕊 沈丽霞[1] ZONG Rui;SHEN Li-xia(Department of Pharmacy, Hcbci North University, Zhangjiakou, 075000, Chin)

机构地区：[1]河北北方学院药学系

出　　处：《神经药理学报》2015年第6期21-29,共9页Acta Neuropharmacologica

基　　金：河北省自然科学基金资助项目(No.H2012405016);河北省教育厅资助项目(No.Z2013069)

摘　　要：聚合物胶束通常由具有两亲性或带有反向电荷的共聚物在水中聚集而成。疏水性嵌段和亲水性嵌段构成胶束的核-壳结构。拥有亲水性外壳以及纳米级粒径（约为10-100 nm）的聚合物胶束不仅能够使其不易被网状内皮系统（reticuloendothelial system,RES）识别吞噬,并且可以通过实体瘤的高通透性和滞留效应（enhanced permeability and retention effect,EPR effect）实现药物胶束对癌组织和炎性组织的被动靶向作用。聚合物胶束可以作为抗癌、抗炎、基因治疗药物的载体。该文总结并分析了聚合物胶束的研究进展,包括胶束的分类组成、制备、胶束的特征、药物胶束的释放以及聚合物胶束的应用。Polymeric micelles are composed of copolymers,which are amphiphilic or oppositely charged in the aqueous solution. The hydrophobic and hydrophilic blocks form core and shell structure of the polymeric micelles. The hydrophilic shell and nanoscale particle size（10-100 nm） of the polymeric micelles not only escape recognizing and up taking by the reticuloendothelial system（RES）,but also passively target cancer and inflammatory tissue by enhanced permeability and retention effect（EPR）. Polymeric micelles are the carrier of anticancer,anti-inflammatory and gene therapy medicine. In this review,we summarized the progress of the polymeric micelles,including the classification of the polymeric micelles,micelles preparation,characteristics,drug release and the application of the polymeric micelles.

关 键 词：纳米 聚合物胶束 药物载体 

分 类 号：R944.9[医药卫生—药剂学]