富勒烯衍生物与抗癌药物分子连接的研究进展  

Progress on the Connection between Fullerene Derivatives and Anticancer Drugs

作　　者：王兴浩[1] 刘文迎 张静[1] 

机构地区：[1]郑州大学化工与能源学院

出　　处：《化学试剂》2018年第2期103-108,131,共7页Chemical Reagents

摘　　要：富勒烯及其衍生物可广泛作为化学药物和基因药物的转运载体。把富勒烯与抗癌药物进行连接,可以改善疏水性药物的生物相容性,通过高通透性和EPR效应聚集在靶组织,得到的富勒烯衍生物具有富勒烯和抗癌药物的双重特性,提高了抗癌药物的活性和生物利用度。对富勒烯及其衍生物耦合脱氢枞胺、阿霉素、紫杉醇等抗癌药物的研究进展进行了综述。Fullerene derivatives can be widely used as the chemical drug and gene drug delivery vector.The fullerene and anticancer drug connection,not only can improve the biocompatibility of hydrophobic drugs,and gathered in the target tissue via high pass and the EPR effect,and has dual characteristics of fullerene and the anticancer drug obtained fullerene derivatives,improve the activity and bioavailability of anticancer drugs.Progress of the fullerene connection dehydroabietylamine,doxorubicin,paclitaxel and other anticancer drugs were reviewed.

关 键 词：富勒烯衍生物 脱氢枞胺 阿霉素 紫杉醇 抗癌药物 

分 类 号：TQ463[化学工程—制药化工]