体内药物累积法研究白血康的表观药物动力学  

STUDIES ON APPARENT PHARMACOKINETICS OF BAIXUEKANG BY DRUG ACCUMULATION METHOD

作　　者：王晓波[1] 兰学山[1] 邢山闽 单建宁 

机构地区：[1]中国人民解放军第210医院临床药理室,大连116021

出　　处：《中国医药工业杂志》1991年第4期167-169,共3页Chinese Journal of Pharmaceuticals

摘　　要：采用体内药物累积法测定小鼠 ip 白血康后的体内过程和药动学参数,白血康在小鼠体内的过程符合二室开放模型,模型方程为:体存率%=87.1711e^(-1.0952t)+138.1771e^(-0.0272t),t_(1/2)α=0.6328h,t_1/2β=25.48h,k_(21):0.6821h^(-1),k_(12)=0.3966h^(-1),k_(10)=0.0437h^(-1),Vc=3.55L/kg.Apparent pharmacokinetics of Baixuekang were determined bydrug accumulation method.Its apparent pharmacokinetics in mice fitted into two-compartment model.The equation of two-compartment was:residual%=87.1711e^(-1.0952t)+138.1771e^(0.0272t),t_(1/2α)=0.6328h^(-1),t_(1/2β)=25.48h^(-1),k_(21)=0.6821h^(-1),k_(12)=0.3966h^(-1),k_(10)=0.0437h^(-1),V_c=3.55L/kg.

关 键 词：白血康 药物累积法 药物动力学 

分 类 号：R979.1[医药卫生—药品]