贵阳市城区40～80岁居民正常血清TSH水平与代谢综合征及其组分的相关性研究  

Study on the correlation between normal serum TSH level and components of metabolic syndrome in Guiyangurban residents aged 40-80 years

作　　者：杨洋 时立新 张巧 彭年春 胡颖 

机构地区：[1]贵州医科大学附属医院内分泌代谢病科,贵阳550004

出　　处：《中华内分泌代谢杂志》2018年第1期34-37,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：贵州省省长基金临床应用课题专项研究黔省专合字（2012）100号;国家重点研发计划资助（2016YFc0901200）;2016年贵州省I临床重点专科培育项目（SZD-2016-01）

摘　　要：2011年5月~10月在贵阳市城区云岩区采用整群抽样方法抽取居住5年及以上者10 140名，年龄40~80岁，所有调查对象均进行详细的流行病学问卷调查，收集基本资料，测量体重指数（BMI）、腰围、血压、血糖、血脂、胰岛素及甲状腺功能。结果显示，入组甲状腺功能正常者7 743名，代谢综合征（MS）为40.3%，其中男性27.4%，女性45.6%。MS组TSH水平高于非MS组[（2.63±1.01）对（2.53±1.04）mU/L，P〈0.01]。将正常TSH水平按四分位数分为4个亚组，结果显示BMI、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）在4个亚组间差异有统计学意义（P〈0.05）。校正年龄、BMI、稳态模型评估的胰岛素抵抗指数（HOMA-IR）后，正常TSH水平与TG、空腹胰岛素和MS患病率呈显著正相关（P〈0.05），logistic回归分析表明TSH是影响MS的危险因素（OR＝1.056，95%CI 1.004~1.111）。A total of 10 140 adult residents aged 40-80 years living for more than five years in Yunyan district of Guiyang were recruited by cluster sampling method from May to October, 2011. The epidemiological questionnaire investigations were performed in all subjects and basic information was collected. Body mass index（BMI）, waist circumference, blood pressure, blood glucose, blood lipids, serum insulin, and TSH levels were measured. The results showed that the prevalence of metabolic syndrome（MS）was 40.3% in 7 743 subjects with normal thyroid function, which was 27.4% for men and 45.6% for women. The TSH level in MS group was significantly higher than that in non-MS group [（2.63±1.01 vs 2.53±1.04）mU/L, P〈0.01]. Significant differences in BMI, triglycerides（TG）, and high density lipoprotein cholesterol（HDL-C）were found in groups with different TSH levels（P〈0.05）. The normal TSH level was positively related to TG, fasting insulin, and the prevalence of MS after adjusting for age, BMI, and homeostasis model assessment for insulin resistance（P〈0.05）. Logistic regression showed that the TSH was an influencing factor for MS（OR=1.056, 95%CI 1.004-1.111）.

关 键 词：代谢综合征 促甲状腺素 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌]