催乳素调控胰岛β细胞功能的研究进展  

Progress of prolactin in regulating the function of pancreatic β cells

作　　者：赵馨[1] 吴亚 祝辉[2] 武晓泓[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,210029 [2]南京医科大学生殖医学国家重点实验室

出　　处：《中华内分泌代谢杂志》2018年第1期79-82,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目（81261120566、81070621）,南京医科大学生殖医学重点实验室开放基金课题（SKLRM.KA201604）

摘　　要：催乳素是调控细胞生长发育的一种多肽激素。近年来的研究表明催乳素还参与糖代谢调控，与血糖稳态密切相关。本文就催乳素与胰岛β细胞的相关研究进展进行综述，包括对催乳素及其受体的认识、催乳素与糖代谢调控、催乳素与胰岛β细胞增殖、凋亡和分泌的关系。Prolactin is a polypeptide hormone that regulates cell growth and development. Recent studies have shown that prolactin is involved in the regulation of glucose metabolism and is closely related to blood glucose homeostasis. This paper is to review the research progress of prolactin in islet β cells, including the understanding of prolactin and its receptor, the associations of prolactin with glucose metabolism, and the proliferation, apoptosis and secretion of pancreatic beta cells.

关 键 词：催乳素 催乳素受体 糖代谢 胰岛Β细胞 

分 类 号：R587.1[医药卫生—内分泌]