基于模糊层次分析法优选复方黄芪水浸膏提取工艺路线  

Optimization of extraction process route of Compound Huangqi Water Extract based on fuzzy analytic hierarchy process evaluation model

作　　者：孙铭忆 李冰韶 王永洁 刘葭[1] 吴清[1] 李园[2] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]中日友好医院中西医结合肿瘤内科,北京100029

出　　处：《中草药》2018年第2期325-329,共5页Chinese Traditional and Herbal Drugs

基　　金：北京市科技计划"十病十药"研发项目(Z161100001816015)

摘　　要：目的采用模糊层次分析法优选复方黄芪水浸膏最佳提取工艺路线。方法构造多层次指标评价模型,分为目标层、准则层、方案层;选取指标性成分定量测定、药效学指标作为准则层,方中指标性成分黄芪甲苷转移率、京尼平苷酸转移率、腹水量、腹水中血管内皮生长因子(vascular endothelial growth factor,VEGF)、胸腺指数为方案层,采用模糊层次分析法(FAHP)为指标赋权,得到各工艺路线加权综合得分。结果方案层指标权重(ω)由高到低依次为腹水量(ω=0.255)、腹水中VEGF量(ω=0.215)、胸腺指数(ω=0.200)、黄芪甲苷转移率(ω=0.170)、京尼平苷酸转移率(ω=0.160)。得到的评分高低顺序为工艺a>工艺c>工艺b,由此确立复方黄芪水浸膏的最佳提取工艺为工艺a,即全方水提。结论选取化学指标结合药效学指标,通过模糊层次分析法赋权,优选出复方黄芪水浸膏的提取工艺路线,为临床经验方研制成药的工艺优选提供研究思路与方法。Objective To optimize extraction process route of Compound Huangqi Water Extract by using fuzzy analytic hierarchy process （FAHP）. Methods The multi-level index evaluation model was established and divided into target layer, criterion layer and index layer. The criterion layer included indicative components and pharmacodynamics index. The index layer consisted of transfer rate of astragaloside and geniposidic acid, volume of ascites, content of VEGF in ascites and thymus index. All the indexes were weighted by using FAHP, and the comprehensive score of each extraction process route was obtained. Results The important degrees （w） of each index from high to low were： volume ofascites （w = 0.255）, content of VEGF in ascites （w = 0.215）, thymus index （w = 0.200）, transfer rate ofAstragaloside （w = 0.170）, and transfer rate of geniposidic acid （w = 0.160）. The scores from high to low were： route a 〉 route c 〉 route b. Hence, the optimized extraction process route of Compound Huangqi Water Extract was reflux extraction with water. Conclusion This experiment combined chemical index and pharmacodynamics index as evaluation index. Weighting coefficient of all the indexes was decided by FAHP-based evaluation. It can provide research ideas and methods for optimizing extraction process of clinical empirical formula in the development of patent medicine.

关 键 词：复方黄芪水浸膏 模糊层次分析法 提取工艺路线 化学指标 药效学指标 

分 类 号：R284.2[医药卫生—中药学]