大肠癌肿瘤标志物联合多层螺旋CT诊断老年大肠癌的价值研究  

Study on the combined value of multi-slice spiral CT in the diagnosis of elderly colorectal cancer colorectal cancer tumor markers

作　　者：吴明[1] 石锋[1] 杨维伟[1] 

机构地区：[1]天门市第一人民医院放射科,湖北天门431700

出　　处：《海南医学院学报》2018年第2期280-282,共3页Journal of Hainan Medical University

基　　金：湖北省自然科学基金项目(993137)~~

摘　　要：目的:探讨大肠癌肿瘤标志物联合多层螺旋CT诊断老年大肠癌的价值。方法:选择我院2016年1月~2017年9月期间收治的老年大肠癌患者73例作为观察组,老年肠道良性病变患者64例作为对照组。采集血清标本,采用罗氏发光免疫分析仪测定癌胚抗原(CEA)、癌相关抗原72-4(CA72-4)、糖类抗原19-9(CA19-9)、细胞角蛋白19的可溶性片段(CYFRA21-1)含量;且采用多层螺旋CT检查。结果:观察组血清CEA、CA72-4、CA19-9和CYFRA21-1水平明显高于对照组,差异有统计学意义(P<0.05);观察组CEA、CA72-4、CA19-9、CYFRA21-1及联合检测阳性率明显高于对照组,差异有统计学意义(P<0.05);观察组MSCT检查阳性率高于对照组,差异有统计学意义(P<0.05);肿瘤标志物联合MSCT检查大肠癌阳性率高于肿瘤标志物联合检测和MSCT检查,差异有统计学意义(P<0.05);但肿瘤标志物联合检测和MSCT检查大肠癌阳性率比较无统计学差异(P>0.05)。结论:大肠癌肿瘤标志物联合多层螺旋CT诊断老年大肠癌具有重要研究价值,可明显提高诊断阳性率。Objective:To investigate the value of tumor markers in colorectal cancer with multi-slice spiral CT in the diagnosis of elderly colorectal cancer.Methods:In our hospital from January 2016 to September 2017 year period in elderly patients with colorectal cancer and 73 cases as the observation group;selection of our hospital in January 2016 to September 2017 were elderly patients with intestinal benign lesions in 64 cases as control group.Serum samples were collected,and the contents of CEA,CA72-4,CA19-9 and CYFRA21-1 were determined by Roche luminous immunoassay analyzer,and multi slice spiral CT was used.Results:the serum levels of CEA,CA72-4,CA19-9 and CYFRA21-1 levels were significantly higher than the control group(P<0.05);the observation group CEA,CA72-4,CA19-9,CYFRA21-1 and the positive rate of combined detection was significantly higher than the control group(P<0.05);positive rate of the observed group MSCT was higher than the control group(P<0.05);positive rates of tumor markers combined with MSCT examination of colorectal cancer is higher than that of combined detection of tumor markers and MSCT examination(P<0.05);but the tumor markers had no significant difference in the positive rate of combined detection and MSCT detection of colorectal cancer(P>0.05).Conclusion:Colorectal cancer tumor markers combined with multi-slice spiral CT in the diagnosis of colorectal cancer in elderly has important research value,can significantly improve the positive rate of diagnosis.

关 键 词：肿瘤标志物 多层螺旋CT 大肠癌 

分 类 号：R445.3[医药卫生—影像医学与核医学] R735.3[医药卫生—诊断学]