无溶剂研磨法合成酰基二茂铁2-氨基-5-取代-1,3,4-噻二唑Schiff碱  

SOLVENT-FREE GRINDING SYNTHESIS OF ACYLFERROCENE 2-AMINO-5-SUBSTITUTED-1,3,4-THIADIAZOLE SCHIFF BASES

作　　者：刘玉婷[1] 王忠宇 尹静怡 尹大伟[1] 

机构地区：[1]陕西科技大学轻化工助剂化学与技术教育部重点实验室,陕西西安710021

出　　处：《精细石油化工》2018年第1期1-5,共5页Speciality Petrochemicals

基　　金：973项目(2014CB260411);陕西省教育厅重点实验室项目(13J017)

摘　　要：以酰基二茂铁和2-氨基-5-取代-1,3,4-噻二唑为原料,在室温下采用固相研磨法合成了13种含二茂铁基Schiff碱。考察了催化剂对固相法的影响,实验表明:对甲苯磺酸催化效果最好,使反应在10~15min内完成,收率达85%以上。与液相法相比,固相法具有无需溶剂、反应条件温和、反应时间短、操作简单、设备要求低、收率高等优点。The 13 kinds of ferroceneyl Schiff base were synthesized by solid solid-phase method from acylferrocene and 2-amino-5-substituted-1,3,4-thiadiazole, and effects of catalyst on the reaction were explored. The result showed that the catalyst of PTSA could shorten the reaction time to 10 - 15 minutes and increase the yield to more than 85%. Compared with liquid phase method, the solid-phase method had advantages of mile condition, short reaction time, simple procedure, higher yields.

关 键 词：固相法 研磨 酰基二茂铁 噻二唑 SCHIFF碱 

分 类 号：O627.81[理学—有机化学]