夏枯草颗粒对气滞血瘀证乳腺增生模型大鼠下丘脑-垂体-性腺相关激素分泌和单胺类神经递质含量的影响  

Effects of the Xiakucao granule on hypothalamus pituitary-gonad related hormone secretion and monoamine neurotransmitter content in HMG rats with the Qizhi Xueyu syndrome

作　　者：郭娜[1] 

机构地区：[1]山西省中医院,山西太原030012

出　　处：《中医临床研究》2017年第36期97-100,共4页Clinical Journal Of Chinese Medicine

基　　金：山西省中医院院级课题(课题代码:201301)

摘　　要：目的:研究夏枯草颗粒对气滞血瘀证乳腺增生模型大鼠的作用及机理。方法:大鼠采用肌骨注射苯甲酸雌二醇、黄体酮,联合慢性不可预见性刺激建立气滞血瘀证乳腺增生病大鼠模型。造模成功后连续灌胃夏枯草颗粒4周,测定大鼠第二对乳房大小,显微镜下观察各组大鼠乳腺组织的病理形态学变化。ELISA法测定大鼠测定血清中相关性激素和单胺类神经递质含量。结果:夏枯草颗粒可显著降低气滞血瘀证乳腺增生大鼠模型血清中E2含量(P<0.05),血清中P含量和5-HT有所升高;乳腺病理切片显示腺泡增生减轻,分泌物减少。结论:夏枯草颗粒可抑制气滞血瘀证乳腺增生病大鼠乳腺组织的增生,可能与调节大鼠体内雌、孕激素水平的平衡有关。Objective: To investigate the pharmacodynamism and mechanism of the Xiakucao granule on HMG rats of the Qizhi Xueyu syndrome. Method: The model rat of HMG was prepared by injecting estradiol in the thigh muscle of the rats and progesterone consecutively, while the rats model was established to bear chronic unpredictable stress. Rats were treated with the Xiakucao granule or positive control drugs for four weeks. The concentrations of sex hormone and monoamine neurotransmitter in rat serum were examined by using ELISA kits, and the morphology of mammary gland tissue in all group rats was observed with microscope. Result:The Xiakucao granule could significantly decrease E2, 5-HT and increase P concentrations of HMG rats. It also eliminated hyperplasia of lobules and gland alveolus compared with the model group. Conclusion: The Xiakucao granule could significantly regulate the sex hormone disorder of HMG rat models, and could eliminate the formation of HMG.

关 键 词：夏枯草颗粒 乳腺增生病大鼠 性激素 乳腺 

分 类 号：R271.44[医药卫生—中医妇科学]