保胎无忧片联合地屈孕酮片治疗先兆流产70例临床观察  

Clinical Observation of Baotaiwuyou Tablets Combined with Dydrogesterone Tablets for Treating Threatened Abortion in 70 Cases

作　　者：丛建萍[1] 金良怡[1] 唐欢 

机构地区：[1]辽宁省沈阳市妇婴医院妇产科,辽宁沈阳110011

出　　处：《中国药业》2018年第2期66-68,共3页China Pharmaceuticals

摘　　要：目的观察保胎无忧片联合地屈孕酮治疗先兆流产的临床疗效。方法选择医院2015年8月至2017年2月收治的先兆流产患者140例,采用随机数字表法分为对照组和观察组,各70例。两组患者均口服地屈孕酮片(首次剂量40 mg,之后每次10 mg,每日2次),观察组联合口服保胎无忧片(每次4片,每日3次),直到患者阴道出血及其他相关症状体征均消失,妇科超声提示原始心管搏动。结果观察组总有效率为97.14%,显著高于对照组的85.71%(P<0.05);治疗后,两组患者血清人绒毛膜促性腺激素(HCG)、孕酮(P)、雌二醇(E_2)及血清孕酮诱导的封闭因子(PIBF)水平均较治疗前升高,且观察组升高水平明显高于对照组(P<0.05);观察组患者阴道流血时间及下腹坠痛时间均明显短于对照组患者(P<0.05);观察组患者保胎成功率为87.14%,明显高于对照组的72.86%(P<0.05);对照组患者成功分娩51例,明显少于观察组的61例(P<0.05);分娩并发症主要为前置胎盘、胎膜早破及产后出血,观察组并发症总发生率低于对照组,但组间差异不显著(P>0.05);两组患者不良反应发生率相近(11.43%比10.00%,P>0.05)。结论保胎无忧片联合地屈孕酮片治疗先兆流产疗效肯定,可显著升高患者体内P,HCG,PIBF及E_2激素水平,提高分娩成功率,且不良反应较轻微,值得临床推广。Objective To investigate the clinical effect of Baotaiwuyou Tablets combined with Dydrogesterone Tablets in the treatment of threatened abortion. Methods Totally 140 patients with threatened abortion admitted to our hospital from August 2015 to February 2017 were ran domly divided into the control group and the observation group,70 cases in each group. The patients in the two groups were giv en Dydrogesterone Tablets（ the first dose was 40 mg,and then 10 mg each time,twice a day）,on this basis,the observation group was given Baotaiwuyou Tablets（ 4 tablets each time,3 times a day） until the patients＇ vagina bleeding and other symptoms and signs disappeared,gynecological ultrasound prompted the original heart beat. Results The total effective rate of the observation group was 97. 14%,which was significantly higher than 85. 71% of the control group（ P 0. 05）. After treatment,The levels of serum human chorionic gonadotropin（ HCG）,progesterone（ P）,estradiol（ E_2） and progesterone-induced blocking factor（ PIBF） in the two groups were significantly higher than those before treatment,and the those in the observation group were significantly higher than those in the control group（ P 0. 05）. The time of vaginal bleeding and the duration of pain in the lower abdomen in the observation group were significantly shorter than those in the control group（ P 0. 05）. The success rate of miscarriage in the observation group was 87. 14%,which was significantly higher than 72. 86% of the control group（ P 0. 05）. The number of successful pregnant women in the control group was 51 cases,which was significantly less than 61 cases in the observation group（ P 0. 05）. The main complications of delivery were placental presentation,premature rupture of fetal membranes and postpartum hemorrhage,the total incidence rate of complications in the observation group was lower than that in the control group,but there was no significant difference between the two groups（ P 0. 05）.The incidence rates of

关 键 词：先兆流产 保胎无忧片 地屈孕酮片 人绒毛膜促性腺激素 孕酮 孕酮诱导的封闭因子 雌二醇 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R977.12[医药卫生—药学]