自微乳释药系统在西药制剂中的应用  

Application of Self-Microemulsifying Drug Delivery System in Pharmaceutical Preparation

作　　者：刘静[1] 

机构地区：[1]南开大学医院药剂科,天津300073

出　　处：《中国药业》2018年第1期4-8,共5页China Pharmaceuticals

摘　　要：目的综述自微乳释药系统的最新研究进展。方法查阅国内外文献资料,并进行整理、归纳,阐述自微乳释药系统的基本理论、处方组成和质量评价,以及近年来在西药制剂中的应用。结果自微乳释药系统能显著增加某些难溶性药物的吸收和生物利用度,应用前景很好。结论自微乳释药系统仍存在一些问题,尚需在更多学科领域加强研究,以推动自微乳释药系统的创新和开发。Objective To review the latest research progress of self-microemulsifying drug delivery system. Methods The literature at home and abroad were summarized, the basic theory, formulation and quality evaluation of self-microemulsifying drug delivery system were expatiated in detail, and the application of self-microemulsifying drug delivery system in pharmaceutical preparation in recent years was introduced. Results The self-microemulsitying drug delivery system had a good prospect, it could significantly enhance the absorption and bioavailability of some insoluble drugs. Conclusion There are still some problems in the self-microemulsifying drug delivery system,and it needs to be strengthened in more discipline fields to promote its innovation and development.

关 键 词：自微乳释药系统 西药制剂 溶解度 体外溶出度 生物利用度 

分 类 号：R945[医药卫生—微生物与生化药学]