合并桥本氏甲状腺炎的甲状腺乳头状癌淋巴结转移的危险因素分析  

Risk factors for lymph node metastasis in papillary thyroid carcinoma coexistent with Hashimoto's thyroiditis

作　　者：杨贤[1] 黄欣欣 王旖 白淘[2] 

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学第一医院病理科

出　　处：《中国现代医药杂志》2018年第1期22-25,共4页Modern Medicine Journal of China

摘　　要：目的分析合并桥本氏甲状腺炎的甲状腺乳头状癌颈部淋巴结转移的危险因素。方法采用回顾性分析方法,收集甲状腺乳头状癌合并桥本氏甲状腺炎患者的临床病理资料,如年龄、性别、肿瘤最大径、多灶性、淋巴结转移情况等,经单因素及多因素分析确定淋巴结转移的危险因素。结果收集病例112例,男21例,女91例;其中45例发生颈部淋巴结转移(40.17%);肿瘤最大径≤1cm者69例;多灶者42例;有砂粒体77例。单因素分析显示,年龄≥55岁、较小的肿瘤直径、多灶性和存在砂粒体是淋巴结转移的危险因素。多因素分析显示,年龄≥55岁、较小肿瘤直径以及肿瘤多灶性是颈部淋巴结转移的独立危险因素。结论年龄≥55岁、较小肿瘤直径以及多灶性是甲状腺乳头状癌合并桥本氏甲状腺炎淋巴结转移的危险因素,提示其淋巴结转移可能。Objective To evaluate the risk factors of lymph node metastasis（LNM） in patients with papillary thyroid cancer（PTC） coexisting with Hashimoto＇s thyroiditis（HT）. Methods Retrospectively studied the information of the patients with PTC and HT,including age gender,tumor size,mulifocality,lymph node metastasis. Multivariate analysis was performed to identify risk factors of LNM. Results Among 112 patients,21 cases were male, 91 cases were female. 45 cases had cervical lymph node metastasis（40.17%）;69 cases of maximum diameter of tumors were smaller than 1 cm;42 cases were multifocal;77 cases had psammoma bodies. Univariate analysis showed that age more than or equal to 55 years,smaller tumor diameter,multifocal and psammoma bodies were risk factors for lymph node metastasis. Multivariate analysis showed that age more than or equal to 55 years,smaller tumor diameter and multifocality were independent risk factors for lymph node metastasis. Conclusion Age more than or equal to 55 years,smaller tumor diameter and multifocality are independent risk factors for LNM of patients who have PTC coexistent with HT,which suggest the possibility of lymph node metastasis.

关 键 词：乳头状癌 桥本 淋巴结转移 年龄 砂粒体 

分 类 号：R581.4[医药卫生—内分泌] R736.1[医药卫生—内科学]