不同剂量^(60)Co辐照对风湿痹痛胶囊中异欧前胡素含量的影响  

Effects of Different Dose ^(60)Co Irradiation on Content of Isoimperatorin in Fengshi Bitong Capsule

作　　者：黄木土[1] 谢新民[1] 张美 林兰兰[1] 韩丽萍[1] 

机构地区：[1]广州军区广州总医院药学部,广州510010 [2]清远职业技术学院食品药品学院,清远511500

出　　处：《医药导报》2018年第2期217-219,共3页Herald of Medicine

基　　金：军队医疗机构制剂标准提高计划-治疗内分泌代谢与老年病非标准制剂质量标准提高研究(14ZJZ15-3);广州市科技计划项目-广州市老年慢病患者合理用药重点实验室(201509010012)

摘　　要：目的建立风湿痹痛胶囊中异欧前胡素的含量测定方法,并考察不同剂量^(60)Co辐照对其含量的影响。方法Agilent C_(18)色谱柱(4.6 mm×250 mm,5μm),以乙腈-水(41∶59)为流动相,检测波长为310 nm,流速1.0 mL·min^(-1),柱温30℃。结果异欧前胡素在3.668 96~183.448μg·mL^(-1)范围内线性关系良好(r=1.000 0),平均加样回收率96.42%,RSD=2.61%;辐照剂量2,5和10 kGy对该成分的含量未引起明显变化。结论 HPLC法对风湿痹痛胶囊中异欧前胡素含量测定准确、可行,^(60)Co辐照分虽为10 kGy以下对该制剂中异欧前胡素没有显著影响。Objective To establish a method for isoimperatorin in Fengshi Bitong capsule and to study the effects of different doses of ^(60)Co irradiation on the content of isoimperatorin.Methods The Agilent C_(18) column(4.6 mm × 150 mm,5μm) was used with the mobile phase consisted of acetonitrile-water(41∶59); The flow rate was 1.0 mL·min^(-1),the detection wavelength was at 310 nm,and the column temperature was at 30 ℃.Results Isoimperatorin showed a good linear relationship within a range of 3.668 96-183.448 μg·mL^(-1)(r = 1.000 0).The average rate of recovery was 96.42%,RSD = 2.61%.The content of isoimperatorin in Fengshi Bitong capsule did not change significantly when irradiated by 2,5 and 10 kGy of ^(60)Co.Conclusion The established methods can be used for isoimperatorin determination in Fengshi Bitong capsule with high specificity,accuration and feasibility.The influence was not significant when the irradiation dose was less than 10 kGy.

关 键 词：风湿痹痛胶囊 60Co辐照 异欧前胡素 

分 类 号：R286[医药卫生—中药学] R927.1[医药卫生—中医学]