肌少症对老年进展期胃癌患者根治性胃切除术后并发症的影响  

Effect of Sarcopenia on Postoperative Complications in Elderly Patients with Advanced Gastric Cancer after Radical Gastrectomy

作　　者：马亮亮 张飞宇 王速临 余震[1] 

机构地区：[1]温州医科大学附属第一医院胃肠外科,温州325015

出　　处：《数理医药学杂志》2018年第2期170-173,共4页Journal of Mathematical Medicine

基　　金：国家自然科学基金资助项目(编号:81171857);浙江自然科学基金资助项目(编号:LY12H1004);浙江省卫生厅医学支撑学科-营养学(编号:11-ZC24)

摘　　要：目的:研究肌少症对接受根治性胃切除的老年进展期胃癌患者术后并发症的影响。方法:本研究纳入2015年8月~2017年4月间接受限期胃癌根治术的老年进展期胃癌患者,前瞻性收集患者临床基本信息和术后短期临床结局,根据术前是否存在肌少症分为两组,分析两组患者的基本临床特点及术后并发症的相关危险因素。结果:共纳入184例符合纳入标准的患者,其中男性患者152例,女性患者32例。与非肌少症患者相比,肌少症患者的平均年龄更高(P=0.005),BMI(P<0.001)、白蛋白含量(P=0.008)、血红蛋白含量(P<0.001)更低。术后并发症与贫血(P=0.001)、Charlson合并症指数(P=0.013)以及肌少症(P<0.001)有关。Charlson合并症指数≥2(P=0.012)和肌少症(P<0.001)是老年进展期胃癌患者根治性胃切除术术后并发症的独立危险因素。结论:肌少症能预测老年进展期胃癌患者根治性胃癌切除术术后并发症,Charlson合并症指数≥2和肌少症是术后并发症的独立危险因素。Objective:To explore the effect of sarcopenia on postoperative complications in elderly patients with advanced gastric cancer after radical gastrectomy.Methods:This study was included in elderly patients with advanced gastric cancer who underwent radical gastrectomy from August 2015 to April 2017.The clinical characteristics and postoperative short-term outcome were prospectively collected,and all patients were divided into two groups based on the presence of sarcopenia before operation.Then the basic clinical characteristics and the related risk factors of postoperative complications of the two groups were analyzed.Results:A total of184 patients including 152 males and 32 females met the inclusion criteria and were included in this study.Compared with non-sarcopenia patients,the average age of patients with sarcopenia was higher(P=0.005),and the BMI(P<0.001),albumin content(P<0.008),and the hemoglobin content(P<0.001)of patients with sarcopenia were lower.Postoperative complications were associated with anemia(P=0.001),Charlson complication index(P=0.013)and sarcopenia(P<0.001).In the multivariate analysis,Charlson complication index ≥ 2(P =0.012)and sarcopenia(P <0.001)were the independent risk factors for postoperative complications of the elderly patients with advanced gastric cancer.Conclusion:Sarcopenia can predict the postoperative complications in elderly patients with gastric cancer after radical resection of gastric cancer,and the Charlson complication index ≥ 2 and sarcopenia are the independent risk factors for postoperative complications.

关 键 词：肌少症 老年患者 进展期胃癌 术后并发症 根治性胃切除术:/ 

分 类 号：R656.6[医药卫生—外科学]