血清ANA、SMA、PANCA、LKM及SLA联合检测在自身免疫性肝炎诊断中的应用  

Clinical Application of Combined Detection of Serum ANA,SMA,PANCA,LKM and SLA in the Diagnosis of Autoimmune Hepatitis

作　　者：张珂[1] 侯卫科[1] 

机构地区：[1]河南宏力医院检验科,新乡453400

出　　处：《数理医药学杂志》2018年第2期233-234,共2页Journal of Mathematical Medicine

摘　　要：目的:探讨血清抗核抗体(ANA)、抗平滑肌抗体(SMA)、抗髓过氧化物酶抗体(PANCA)、肝肾微粒体抗体(LKM)及抗可溶性肝抗原抗体(SLA)联合检测在自身免疫性肝炎(AIH)诊断中的应用价值。方法:回顾性分析2015年3月~2017年3月某院268例确诊为自身免疫性肝炎患者的临床资料并设为研究组,并选取同期268例其他类型肝炎患者为对照组,入组的患者均行血清ANA、SMA、PANCA、LKM及SLA自身抗体检测及转氨酶(ALT)、血清胆红素(TBIL)等常规生化检验,比较两组患者的检验结果。结果:两组患者的血清胆红素DBIL、TBIL,γ-谷氨酰转肽酶(γ-GT),白/球比,IgA、IgG、IgM及转氨酶ALT与AST水平比较均无显著性差异(P>0.05),研究组患者ANA、SMA的检出率显著高于对照组,两组比较差异性显著(P<0.05),两组患者PANCA、LKM及SLA检出率比较均无显著性差异(P>0.05)。结论:血清ANA、SMA、PANCA、LKM及SLA自身抗体联合检测有助于诊断自身免疫性肝炎,为临床治疗提供参考。Objective:To explore the application value of combined detection of serum ANA,SMA,PANCA,LKM and SLA in the diagnosis of autoimmune hepatitis.Methods:268 cases of patients with autoimmune hepatitis from March 2015 to March 2017 were selected as research group and another 268 cases of patients with hepatitis of other type were selected as control group.Serum ANA,SMA,PANCA,LKM and SLA autoantibodies and transaminase(ALT),serum bilirubin(TBIL)and other routine biochemical tests were performed in the patients.Then the inspection results were compared.Results:There was no significant difference in DBIL,TBIL,γ-GT,white/ball ratio,IgA,IgG,IgM,ALT and AST level between the two groups(P>0.05).The relevance ratio of ANA and SMA in research group were higher than those in control group,and the difference between the two groups is significant(P<0.05).There was no significant difference of relevance ratio of PANCA,LKM and SLA(P>0.05).Conclusion:The combined detection of serum ANA,SMA,PANCA,LKM and SLA can be helpful in the diagnosis of autoimmune hepatitis and provide a reference for clinical treatment.

关 键 词：自身免疫性肝炎 自身抗体 常规生化 诊断 

分 类 号：R446.6[医药卫生—诊断学]