卡铂和顺铂在大鼠体内的药动学  

PHARMACOKINETICS OF CARBOPLATIN AND CISPLATIN IN RATS

作　　者：李文钧[1] 郑永兴[1] 李延福[1] 席玉莲 彭小英[1] 胡欣[1] 周新伟[1] 

机构地区：[1]浙江省医学科学院,杭州310013

出　　处：《中国医药工业杂志》1991年第5期220-223,共4页Chinese Journal of Pharmaceuticals

摘　　要：应用石墨炉原子吸收法,对国产卡铂和顺铂在大鼠体内的药动学进行了比较。两药的药时过程均可按二室开放模型拟合。卡铂的 T_(1/2β)为14～16h,顺铂为23h。24h 内卡铂经尿排泄90%,顺铂约39%。10mg/kg 顺铂的组织分布及药时曲线下面积分别与60mg/kg 及与30mg/kg 卡铂相近。这些结果与卡铂的肾毒性明显小于顺铂相符合。The pharmacokinetics of carboplatin(1)and cisplatin(2)wasobserved in Spraque-Dawly rats.The serum concentration-time curves were biphasicin the period studied(0～24h),with T_(1/2β) of 14～16h for 1 and 23h for 2,90%of platinum administered was excreted in 24h urine for 1,and about 39% for 2.The mean AUC value for 30mg/kg 1 was 35μg/ml·h,for 10mg/kg 2 was 36μg/ml·h.The distribution of Pt in tissues showed that kidney had the highest concentration.The results accorded with the less nephrotoxicity of 1 in comparison with 2.

关 键 词：卡铂 顺铂 药物动力学 大鼠 

分 类 号：R969.1[医药卫生—药理学]