乌司他丁辅助治疗对脓毒症患者血清NT-proBNP和心肌酶的影响分析  

Analysis of the effect of Ulinastatin adjuvant therapy on serum NT-pro BNP and myocardial enzymes in patients with sepsis

作　　者：张颖[1] 汪阳[2] 袁杉[3] 

机构地区：[1]西安市中心医院重症医学科,西安710003 [2]西安市中心医院烧伤整形科,西安710003 [3]西安市中心医院肾病科,西安710003

出　　处：《中国医学前沿杂志（电子版）》2017年第11期90-93,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨乌司他丁辅助治疗对脓毒症患者血清氨基酸末端B型利钠肽前体(N-terminal proB-type natriuretic peptide,NT-pro BNP)和心肌酶水平的影响。方法采用随机数表法将本院2015年1月至2016年12月接诊的180例脓毒症患者分为试验组和对照组,每组各90例。对照组患者给予血必净注射液治疗,试验组患者在对照组治疗基础上辅助应用乌司他丁注射液治疗,两组患者均连续治疗1周。比较两组患者治疗前后血压、心率、急性生理功能与慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分及炎性因子、血清NT-pro BNP、心肌酶水平。结果治疗后试验组患者心率、C反应蛋白、白介素-6、肿瘤坏死因子-α、心肌肌钙蛋白I、乳酸脱氢酶、肌酸激酶同工酶、NT-pro BNP水平及APACHEⅡ评分均显著低于对照组(P<0.05),血压显著高于对照组(P<0.05)。结论乌司他丁辅助治疗脓毒症,对于降低心肌酶指标、血清NTpro BNP及炎性因子水平均具有显著效果,值得推广应用。ObjectiveTo investigate the efiects of Ulinastatin adjuvant therapy on serum N-terminal pro-B-type natriuretic peptide （NT-proBNP） and myocardial enzymes in patients with sepsis. Method180 cases of sepsis patients in our hospital from January 2015 to December 2016 were randomly divided into experimental group and control group, 90 cases in each group. Patients in control group were treated with Xuebijing injection. Patients in experimental group were treated with Ulinastatin injection on the basis of control group, and both groups were treated continuously for 1 week. The blood pressure, heart rate, acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ） scores and the levels of infiammatory cytokines, serum NT-proBNP, myocardial enzyme were compared between the two groups. ResultThe heart rate, levels of C-reactive protein, interleukin-6, tumor necrosis factor-α, cardiac troponin I, lactate dehydrogenase, creatine kinase isoenzyme, NT-proBNP and APACHE Ⅱ score in experimental group were significantly lower than control group （P 〈 0.05）, the blood pressure was significantly higher than control group （P 〈 0.05）. ConclusionUlinastatin adjuvant treatment of sepsis, for reducing the levels of myocardial enzyme index, NT-proBNP and infiammatory cytokines have a significant efiect, suitable for promotion.

关 键 词：脓毒症 乌司他丁 血清氨基酸末端B型利钠肽前体 心肌酶 炎性因子 

分 类 号：R459.7[医药卫生—急诊医学]