猪繁殖与呼吸综合征病毒非结构蛋白2研究进展  

Research advances in non-structural protein 2 of porcine reproductive and respiratory syndrome virus

作　　者：赵军[1] 徐志文[1,2] 朱玲[1,2] 

机构地区：[1]四川农业大学动物医学院,四川成都611130 [2]四川农业大学动物疫病与人类健康四川省重点实验室,四川成都611130

出　　处：《浙江农业学报》2018年第2期350-356,共7页Acta Agriculturae Zhejiangensis

基　　金：四川省科技支撑计划(2014NZ0043);教育部"长江学者与创新团队发展计划"(IRT13083);四川省"十三五"育种攻关项目(2016NYZ0052);国家"十二五"科技支撑计划(2015BAD12B04-2.3)

摘　　要：猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)是由PRRS病毒(PRRSV)引起的以母猪繁殖障碍和仔猪呼吸困难、病毒血症为典型症状的一种传染性疾病,给世界养猪业带来巨大的经济损失。深入研究PRRSV的相关致病机制可为该病防控奠定理论依据。在对PRRSV的研究中,非结构蛋白2(non-structural protein 2,Nsp2)一直是研究的热点,文章综述了Nsp2与遗传变异、病毒致病性、病毒复制、免疫调控和重组疫苗与分子标签等相关的研究进展。Nsp2基因序列在对疫苗毒株的鉴别诊断中发挥重要作用。Porcine reproductive and respiratory syndrome virus( PRRSV) is the causative agent of porcine reproductive and respiratory syndrome( PRRS). It is an infectious disease that causes complex systemic disease of swine,which most notably affects the respiratory of infected piglets and reproductive systems of infected sows. PRRS causes great economic losses to the swine industry worldwide. The depth study of PRRSV related pathogenic mechanism will lay an important theoretical foundation for the prevention and control of the disease. The non-structural protein 2( Nsp2) is always the hotspot of these PRRSV studies. This review discussed the correlation between Nsp2 and genetic variations,viral pathogenicity,viral replication,immunological functions,recombinant vaccine and molecular signature. Nsp2 gene played an important role in the differential diagnosis of vaccine strains.

关 键 词：猪繁殖与呼吸综合征病毒 非结构蛋白2 遗传变异 病毒复制 分子标签 

分 类 号：S855.3[农业科学—临床兽医学]