声速匹配技术评价慢性乙型肝炎活动度的初步研究  

Preliminary study on evaluation of activity of chronic hepatitis B by velocity matching technique

作　　者：陈丽荣[1] 程立雪[1] 张步林[1] 黄静[1] 蒋忠胜[2] 张炜[1] 戴文斌[3] 

机构地区：[1]广西壮族自治区柳州市人民医院超声科,广西柳州545006 [2]广西壮族自治区柳州市人民医院肝病科,广西柳州545006 [3]广西壮族自治区柳州市人民医院病理科,广西柳州545006

出　　处：《中国医药科学》2017年第23期9-13,20,共6页China Medicine And Pharmacy

基　　金：广西壮族自治区柳州市科学研究与技术开发计划课题(2014J030409)

摘　　要：目的探讨声速匹配技术对慢性乙型肝炎活动度的诊断价值。方法选取经临床诊断的慢性乙型肝炎患者137例作为研究组,同期健康志愿者21例作为对照组。应用SSC技术测定研究对象的肝组织区域速度指数(ZSI)及区域声速度值(ZSS),根据肝组织病理将研究组分为轻度(G1-2,S0-2)、中度(G3,S1-3)及重度(G4,S2-4)组,比较各组的ZSI及ZSS在慢性乙型肝炎严重程度诊断中的价值。结果慢性乙型肝炎患者肝炎轻、中、重度的ZSI及ZSS分别为(21.61±5.74)m/s及(1561.61±5.73)m/s、(27.38±4.95)m/s及(1567.38±4.95)m/s、(30.48±4.03)m/s及(1570.48±4.03)m/s。ZSI诊断慢性乙型肝炎肝炎活动度G≥G1的ROC曲线下面积为0.826,95%可信区间为(0.764,0.889);ZSI=19.38 m/s为截断值,诊断慢性乙型肝炎的灵敏性、特异性分别为72%、95%。ZSS诊断慢性乙型肝炎肝炎活动度G≥G1的ROC曲线下面积为0.814,95%可信区间为(0.748,0.880);以ZSS=1559.5m/s为截断值,诊断慢性乙型肝炎的灵敏性、特异性分别为72%、95%。结论 ZSI及ZSS对慢性乙型肝炎肝炎活动度具有一定的诊断价值,SSC可作为一种肝炎严重程度的评估技术。Objective To investigate the diagnostic value of Sound speed correction（SSC） in the activity of chronic hepatitis B. Methods A total of 137 patients with chronic hepatitis B were selected as the study group,and 21 healthy volunteers were selected as the control group.Zone speed index（ZSI） and regional acoustic velocity（zone speed speed,ZSS） of the liver tissues of the subjects were measured by SSC technique.According to liver pathology, the study group was divided into mild（G1-2,S0-2）,moderate（G3,S1-3） and severe（G4,S2-4） groups,and the value of ZSI and ZSS in the diagnosis of severity of chronic hepatitis B were compared. Results The mild,moderate and severe ZSI and ZSS in patients with chronic hepatitis B were （21.61＋5.74）m/s and （1561.61＋5.73）m/s,（27.38＋4.95）m/s and （1567.38＋4.95）m/s,（30.48＋4.03）m/s and （1570.48＋4.03）m/S.The area under ROC curve with activity of hepatitis B in chronic hepatitis B by ZSI diagnosis was 0.826,95% confidence interval was （0.764,0.889）.ZSI=19.38m/s was cutoff value,and the sensitivity and specificity of diagnosing chronic hepatitis B were 72% and 95% respectively.The area under ROC curve with activity of hepatitis B in chronic hepatitis B by ZSI diagnosis was 0.814,95% confidence interval was （0.748,0.880）.ZSI=19.38m/s was cutoff value,and the sensitivity and specificity of diagnosing chronic hepatitis B were 72% and 95% respectively. Conclusion ZSI and ZSS have certain diagnostic value for the activity of chronic hepatitis B,and SSC can be used as an evaluation technique for the severity of hepatitis.

关 键 词：超声检查 声速匹配 区域速度指数 炎症活动度 

分 类 号：R512.62[医药卫生—内科学]