在简易膀胱容量测定下托特罗定配合间歇导尿重建脑卒中恢复期患者下尿路功能的临床观察  

The clinical observation of Tolterodine combined with intermittent catheterization reconstruction on post-stroke urinary tract function in patients under simple bladder capacity determination

作　　者：李雪红[1] 赵树平[1] 李佳音 

机构地区：[1]黑龙江省农垦总局总医院,黑龙江哈尔滨150088

出　　处：《中国医药科学》2017年第23期222-224,共3页China Medicine And Pharmacy

摘　　要：目的观察在简易膀胱容量测定下托特罗定配合间歇导尿重建脑卒中恢复期患者下尿路功能短期、长期的安全性及有效性。方法 60例脑卒中恢复期神经源性膀胱下尿路功能障碍患者,予托特罗定2mg日两次口服10d配合间歇导尿治疗15d,后过度自行排尿,并记录15d前后、1个月、6个月后的膀胱容量、排尿次数、每次排尿量、残余尿量及泌尿系彩超。结果治疗15d后,患者平均每次导尿量由(180±20)mL增加到(430±20)mL,排尿次数由(10±2)次,减少到(5±1)次,泌尿系彩超示:无肾积水;治疗15d前后差异均有统计学意义(P<0.01);治疗1个月、6个月后膀胱容量测定为(445±8)mL,排尿次数由(4±1)次,残余尿量(16±3)mL,泌尿系彩超示:无肾积水,治疗15d后与治疗后1个月、6个月后膀胱容量、排尿次数差异均无统计学意义(P>0.05)。结论托特罗定配合间歇导尿治疗脑卒中恢复期患者下尿路功能障碍15d、1个月、6个月后无肾积水,恢复并维持正常膀胱容量及排尿日记,过度自行排尿,证明此治疗方法短时间内安全、有效的解决脑卒中患者下尿路功能障碍,并能保证长期的疗效,提高卒中患者生活质量。Objective To observe the short-term and long-term safety and effectiveness of the function of the lower urinary tract of tolterodine combined with intermittent catheterization reconstruction on post-stroke urinary tract function in patients under simple bladder capacity determination. Methods 60 stroke patients with neurogenic bladder of lower urinary tract dysfunction were treated with oral Tolterodine 2mg two times a day, for 10 days, combined with intermittent catheterization for the treatment of 15 days. After overdue urination, the bladder capacity, urination times, urine volume, residual urine volume and urinary color Doppler ultrasound were recorded before and after 15d, 1 months and 6 months. Results After 15 days of treatment, the average amount of urinary catheterization increased from （180±20） mL to （430±20） mL. The number of urination decreased from （10±2） times to （5±1） times. The color Doppler ultrasound showed no hydronephrosis. The difference in the treatment of 15d before and after treatment was statistically significant （P 〈0.01）. After 1 months and 6 months of treatment, the measurement of bladder capacity was （445±8） mL, the number of urination was （4±1） times and the residual urine volume was （16±3） mL. Urinary color Doppler ultrasound showed no hydronephrosis. There was no significant difference in bladder capacity and urination number after treatment of 15d and 1 months and 6 months after treatment （P 〉0.05）. Conclusion Tolterodine with intermittent catheterization in treatment of stroke in convalescent patients with lower urinary tract dysfunction for 15 days, 1 months and 6 months without hydronephrosis, restore and maintain normal bladder capacity and voiding diary, excessive urination, short time to prove this method of treatment in a safe and effective solution for stroke patients with lower urinary tract dysfunction, and to ensure the long-term curative effect, improve the quality of life in patients with stroke.

关 键 词：简易膀胱容量测定 托特罗定 间歇导尿 脑卒中恢复期 下尿路功能 

分 类 号：R246.6[医药卫生—针灸推拿学]