吗丁啉和小剂量红霉素在治疗早产极低出生体重儿喂养不耐受中的效果对比  

Comparison of effect of a small dose of erythromycin and domperidone in the treatment of very low birth weight infants with feeding intolerance

作　　者：孙玲玲[1] 郑义敏[1] 

机构地区：[1]深圳市儿童医院新生儿科,广东深圳518026

出　　处：《中国医药科学》2017年第24期58-60,共3页China Medicine And Pharmacy

摘　　要：目的研究吗丁啉和小剂量红霉素在治疗早产极低出生体重儿喂养不耐受的效果及副作用。方法将2014年5月~2017年5月期间收治的120例早产极低出生体重儿喂养不耐受患儿,根据随机数字表法,分为治疗A组(小剂量红霉素组,n=40)和治疗B组(吗丁啉组,n=40),对照组(n=40)。治疗A组采用常规治疗加小剂量红霉素5mg/(kg·d),每天1次,缓慢静脉给药,给药7~10d。治疗B组在常规治疗的基础上,于喂奶前30min口服或鼻饲吗丁啉混悬液0.3mL/(kg·次),1次/8h,给药7~10d。对照组给予生理盐水0.5mL/(kg·次)作为安慰剂。观察和比较治疗后的喂养不耐受症状的消失时间、恢复出生体重时间、完全胃肠内营养时间、住院时间及治疗副作用的发生情况。结果治疗A组和治疗B组患儿均达到喂养不耐受症状消失、恢复出生体重和完全胃肠内营养等出院标准。比较两个治疗组患儿的达到上述出院标准的时间和出院时间,其差异均无统计学意义(P>0.05)。但是两个治疗组患儿达到以上出院标准和出院时间均明显短于对照组,差异具有统计学意义(P<0.05)。治疗A组患儿发生9例局部疼痛,不良反应发生率为16.4%;治疗B组患儿采用吗丁啉治疗后,未见与吗丁啉相关的不良反应。比较两个治疗组患儿的不良反应发生率,治疗B组明显高于治疗A组,差异具有统计学意义(P<0.05)。结论吗丁啉和小剂量红霉素均可有效改善极低出生体重儿的喂养不耐受症状。两组药物的治疗效果相似,但吗丁啉的副反应可能较小。Objective To study the effects and side effects of domperidone and low-dose erythromycin in the treatment off premature low birth weight infants with feeding intolerance. Methods 120 cases of premature low birth weight infants with feeding intolerance in our hospital from May 2014 to May 2017 were divided into the treatment group A （low-dose erythromycin group, n=40） and group B （domperidone group, n=40） and control group （n=40） according to the random number table. The treatment group A was treated with conventional treatment plus low-dose erythromycin 5mg /（ kg·d）, once time a day, slowly intravenous administration for 7-10d. The control group was given saline 0.5ml/kg everytime as a placebo. The disappearance time of the feeding intolerance symptoms, the time of birth weight recovery, the time of complete enteral nutrition, the length of hospital stay and the side effects of treatment were observed and compared. Results The treatment group A and the treatment group B all reached the discharge criteria of feeding intolerance symptoms disappeared, and restored the birth weight and complete gastrointestinal nutrition. There was no significant difference between the two groups in reaching the discharge standard and discharge time （P 〉0.05）. However, the discharge standard and discharge time of the two treatment groups were significantly shorter than those of the control group, and the difference was statistically significant （P 〈0.05）. 9 cases of local pain occurred in the treatment group A, and the incidence of adverse reactions was 16.4%. There was no adverse reactions associated with domperidone after treatment in treatment group B. Compared the incidence of adverse reactions in two treatment groups, the treatment group B was significantly higher than the treatment group A, the difference was statistically significant （P 〈0.05）. Conclusion A small dose of erythromycin and domperidone can effectively improve the very low birth weight infants with feeding intolerance symptoms. T

关 键 词：吗丁啉 红霉素 极低出生体重儿 喂养不耐受 

分 类 号：R722.6[医药卫生—儿科]