血清25-羟维生素D_3在婴幼儿喘息性疾病中的表达水平及临床意义  

Expression level and clinical significance of serum 25-hydroxy vitamin D_3 in infants with asthmatic diseases

作　　者：郑海涵 刘德云[1] 

机构地区：[1]安徽医科大学第二附属医院儿科,安徽合肥237000

出　　处：《现代医药卫生》2018年第3期381-383,共3页Journal of Modern Medicine & Health

摘　　要：目的探讨血清25-羟维生素D_3[25-(OH)D_3]表达水平与婴幼儿喘息的相关性。方法选取该院2015年3月至2016年3月诊断为婴幼儿喘息性疾病的患儿100例[毛细支气管炎(毛细支气管炎组)50例,喘息性支气管炎(喘息性支气管炎组)50例],诊断为普通肺炎(普通肺炎组)患儿50例,选取同期在该院常规体检婴幼儿50例(对照组),采用随机单盲方法将100例喘息患儿分为常规治疗组和维生素D治疗组,各50例。测量体重分布情况,检测治疗前后血清25-(OH)D_3水平,比较常规治疗组和维生素D治疗组的临床症状消失时间,随访远期复发次数,采用统计学方法进行组间比较。结果毛细支气管炎组和喘息性支气管炎组中血清25-(OH)D_3缺乏的患儿比例均高于普通肺炎组和对照组,差异均有统计学意义(P<0.05),毛细支气管炎组和喘息性支气管炎组体重分布在大于+1SD^+2SD和大于+2SD的患儿比例与普通肺炎组比较,差异均有统计学意义(P<0.05)。治疗前,维生素D治疗组与常规治疗组患儿血清25-(OH)D_3水平比较,差异无统计学意义(P>0.05);治疗后,维生素D治疗组患儿血清25-(OH)D_3水平明显高于常规治疗组,咳嗽气喘消失时间、肺部啰音消失时间、住院时间均明显短于常规治疗组,差异均有统计学意义(P<0.05)。维生素D治疗组患儿半年内喘息再发次数少于常规治疗组,差异有统计学意义(P<0.05)。结论婴幼儿喘息与25-(OH)D_3水平存在一定相关性,补充维生素D对婴幼儿喘息性疾病的治疗起着积极作用。Objective To analyze the correlation between the expression level of 25-hydroxy vitamin D_3[25-(OH)D_3]and asthmatic diseases in infants. Methods From March 2015 to March 2016,100 infants,who were diagnosed as asthmaticdiseases in the hospital,were selected,including 50 cases of capillary bronchitis(capillary bronchitis group)and 50 cases ofasthmatoid bronchitis(asthmatoid bronchitis group);simultaneously 50 infants with common pneumonia(common pneumoniagroup)and 50 infants in the hospital for routine physical examination(control group)were selected. 100 infants with asthmaticdiseases were divided into conventional treatment group and vitamin D treatment group by single blind random,50 cases ineach group. The weight distribution was measured,and the levels of 25-(OH)D_3 before and after treatment were detected. Thetime of symptom reduction was compared between the conventional treatment group and the vitamin D treatment group,thelong-term recurrence rate was followed,and the group comparison was conducted by statistical method. Results The levels ofserum 25-(OH)D_3 deficiency in the capillary bronchitis group and the asthmatoid bronchitis group were higher than that in thecommon pneumonia group and the control group,with statistically significant difference(P<0.05). Compared with the commonpneumonia group,the propotions of children with body weigth more than +1 SD-+2 SD and more than +2 SD in the capillarybronchitis grouop and the asthmatoid bronchitis group has statistically signoficant difference(P<0.05). There was no statistical-ly significant difference on the levels of serum 25-(OH)D_3 between the vitamin D treatment group and the conventional treat-ment group before treatment(P>0.05),while after treatment,the level of serum 25-(OH)D_3 in the vitamin D treatment groupwas higher than that in the conventional treatment group,while the disappearance time of cough and pulmonary rales,length ofhospital stay were obviously shorter,and the difference had statistical significance(P<0.05). The recurrence rate of brea

关 键 词：支气管炎 喘息 维生素D 骨化二醇 婴幼儿疾病 

分 类 号：R725.6[医药卫生—儿科]