眼底动脉硬化与冠状动脉慢血流的关系  

Correlation between eyeground atherosclerosis and coronary slow flow phenomenon

作　　者：李世敬[1] 陈浩[1] 张丽萍[2] 潘黎明[1] 冯静[1] 王军[1] 王德昭[3] 

机构地区：[1]北京市门头沟区医院心内科,北京102300 [2]北京京煤集团总医院社区科,北京102300 [3]首都医科大学附属北京天坛医院心内科,北京100050

出　　处：《临床荟萃》2018年第2期118-121,共4页Clinical Focus

基　　金：北京市门头沟区医院资助课题:冠状动脉慢血流现象的临床相关变量分析(Q20150205)

摘　　要：目的探讨眼底动脉硬化(eyeground atherosclerosis,EA)与冠状动脉慢血流(coronary slow flow,CSF)的相关性。方法回顾性分析2013年1月至2016年12月于北京市门头沟区医院住院行冠状动脉造影检查诊断CSF的患者146例,选取同期101例冠状动脉血流正常(normal coronary artery,NCA)人群作为对照组。所有病例均行眼底照相检查;同时收集病史、血常规、血生化、纤维蛋白原、尿微量白蛋白(UMA)、糖化血红蛋白、高敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)、颈动脉硬化以及室壁运动等指标,评价EA与CSF的相关性。结果(1)CSF组动脉硬化阳性率明显高于NCA组(P<0.05);(2)随着EA程度的增加,CSF的发生率逐渐增加(P<0.05);(3)综合EA、性别、hs-CRP水平以及其他危险因素后,发现EA≥Ⅱ级、女性、高血压、年龄>65岁以及hs-CRP>5mg/L是CSF的预测因子(P=0.009,0.032,0.036,0.015,0.013)。结论随着EA程度的增加,CSF的发生率逐渐增加,EA和CSF现象具有一定的相关性,是CSF的独立预测因子。Objective To explore the correlation between eyeground atherosclerosis(EA)and coronary slow flow(CSF).Methods A retrospective analysis was performed in 146 patients with CSF and 101 patients with normal coronary flow(NCA)in the hospital from January 2013 to December 2016.All cases were examined by fundus photography,and underwent medical history collection,blood routine,biochemical,fibrinogen,urine microalbumin(UMA),glycosylated hemoglobin,high sensitive C-reactive protein(hs-CRP)and carotid atherosclerosis test.The correlation between EA and CSF was evaluated.Results(1)The positive rate of EA in CSF group was significantly higher than that in group NCA(P <0.05);(2)With the increase of EA,the incidence of CSF increased gradually(P <0.05);(3) Synthesis consideration of EA,gender,hs-CRP and other risk factors,it revealed that EA≥ Ⅱ grade,female,hypertension,age>65 years,hs-CRP>5 mg/L were predictors of CSF(all P <0.05 or<0.01).ConclusionWith the increase of EA,the incidence of CSF increased gradually,there are certain correlation between EA and CSF,EA is an independent predictor of CSF.

关 键 词：冠状动脉硬化 眼疾病 血流速度 C反应蛋白质类 

分 类 号：R541.4[医药卫生—心血管疾病]