医院2016年金黄色葡萄球菌耐药性分析  

Drug Resistance Analysis of Staphylococcus Aureus Strains in Beijing Luhe Hospital in 2016

作　　者：张晓兰[1] 李晓辉[2] 张芳[3] 陈世财[1] 

机构地区：[1]首都医科大学附属北京潞河医院药剂科,北京101100 [2]首都医科大学附属北京潞河医院呼吸科,北京101100 [3]首都医科大学附属北京潞河医院检验科,北京101100

出　　处：《医学综述》2018年第2期409-412,共4页Medical Recapitulate

摘　　要：目的了解医院不同标本来源的金黄色葡萄球菌耐药状况,为临床治疗金黄色葡萄球菌感染提供用药依据。方法收集2016年1—12月首都医科大学附属北京潞河医院住院患者不同标本中分离出的金黄色葡萄球菌284株,采用纸片扩散法(K-B法)对金黄色葡萄球菌进行药物敏感试验,根据2016年美国临床和实验室标准化协会指南判定药物敏感结果。结果 284株金黄色葡萄球菌感染标本主要来自于痰液、分泌物和血液,分别占53.2%、35.6%和3.5%。除复方磺胺甲口恶唑、克林霉素、红霉素外,痰标本的耐药率高于分泌物标本和血标本。耐甲氧西林的金黄色葡萄球菌(MRSA)检出率为42.6%,甲氧西林敏感的金黄色葡萄球菌(MSSA)检出率为57.4%,未发现对万古霉素、利奈唑胺耐药的金黄色葡萄球菌。结论 MRSA对多种抗菌药物有较高的耐药性,MRSA耐药性高于MSSA,MSSA对大部分抗菌药物仍保持较好的敏感性,医院应定期对金黄色葡萄球菌进行监测,合理选用抗菌药物。Objective To investigate the distribution and drug resistance of Staphylococcus aureus in our hospital,so as to provide reasonable basis of antibiotics for the clinical treatment of S. aureus infection. Methods By using disc diffusion( K-B method),the susceptibility testing in 284 samples from inpatient infected with S. aureus from Jan. 2016 to Dec.2016 was carried out. The susceptibility testing results were determined according to the CLSI standard in 2016. Results The 284 strains of S. aureus were mainly isolated from sputums,secretions and blood,accounting for 53. 2%,35. 6% and3. 5%,respectively. The drug resistance rate of sputum specimen was higher than that of the secretion and blood except for sulfamethoxazole complex( SMZco),clindamycin and erythromycin. The detection rate of methicillin resistant S. aureus( MRSA) was 42. 6%,of methicillin sensitive S. aureus( MSSA) was 57. 4%,no S. aureus has been found to be resistant to vancomycin and linazolamide. Conclusion MRSA has high resistant rates to multiple antimicrobial agents,and the drug resistance of MRSA is higher than that of MSSA. MSSA still maintains good sensitivity to most antimicrobial agents. We need a regular monitoring of S. aureus,to keep rational selection of antibiotics.

关 键 词：金黄色葡萄球菌 耐甲氧西林金黄色葡萄球菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]